N/A
Completed N=23
Examining a Wheelchair Exercise-training Intervention for Persons With Multiple Sclerosis
Source: ClinicalTrials.gov NCT05888727 ↗Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcomePrimary: Study Feasibility: Number of Participants Recruited — 24 Participants
Summary
The goal of this randomized controlled clinical trial is to examine the feasibility and initial efficacy of undertaking and delivering a novel, stakeholder-informed exercise training program for wheelchair users with multiple sclerosis. The main questions it aims to answer are:
* Is the study feasible as measured by participant recruitment (24 participants total), retention (80%), and safety (adverse events)?
* Is the study acceptable as measured by participant satisfaction and perceptions using an evaluation survey and semi-structured interviews?
* Is there significant change in following the 16-week study in metabolic health outcomes, MS symptoms, and exercise behavior change? Participants will be randomized to complete the 16-week SPIN exercise training program or WellMS attention/contact wellness program.
Researchers will compare the SPIN and WellMS groups to determine if there is a significant difference in metabolic health outcomes, MS symptoms, and exercise behavior change.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Study Feasibility: Number of Participants Recruited |
24 | — |
| PRIMARY Study Feasibility: Number of Participants Retained |
10; 10 | — |
| PRIMARY Study Feasibility: Number of Participants With Study-Related Adverse Events |
1; 0 | — |
| SECONDARY Acceptability: Number of Participants With Positive Perceptions During Semi-Structured Interview |
9; 8 | — |
| SECONDARY Acceptability as Measured by the Post-intervention Acceptability Survey |
4.5; 4.56 | — |
Eligibility Criteria
Inclusion Criteria
- diagnosis of MS
- self-reported use of a wheelchair (i.e., manual wheelchair, power wheelchair, or scooter) >50% of the time
- age of 18 years or older
- relapse free for the past 30 days
- being non-active defined as not engaging in regular physical activity (30 minutes accumulated per day) on more than 2 days of the week during the previous 6 months (i.e., not meeting current physical activity guidelines for MS)
Exclusion Criteria
- during telephone screening participants will complete an exercise pre-participation health screen and if participants report any symptoms or conditions contradictive of exercise then physician clearance will be required before enrollment
Data sourced from ClinicalTrials.gov (NCT05888727). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.