N/A N=36 Randomized Single-blind Treatment

iCBT With TMS in Patients With MDD

Major Depressive Disorder

Bottom Line

View on ClinicalTrials.gov: NCT05988619 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2025

Primary outcome: Primary: Hamilton Depression Rating Scale (HAM-D) — 20.4375; 21.7692; 11.3333; 11.9231 score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Transcranial Magnetic Stimulation (Device); Internet-Based Cognitive Behavioral Therapy (Behavioral); Psychoeducation (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of California, Los Angeles
Primary completion: Sep 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Hamilton Depression Rating Scale (HAM-D)	20.4375; 21.7692; 11.3333; 11.9231	—
PRIMARY Temporal Experience of Pleasure Scale (TEPS)	59.1875; 58.75; 61.8125; 73.5; 65.0833; 73.3333	—
PRIMARY Inventory of Depressive Symptomatology (IDS)	42.4444; 42.0556; 29.2222; 25.9412	—
PRIMARY Dimensional Anhedonia Rating Scale (DARS)	78.125; 75; 90.2667; 104.1429; 73.3846; 88.25	—

Summary

Major Depressive Disorder (MDD) is a common mental health diagnosis. While there are many approaches to the treatment of MDD, current treatments of MDD often do not substantially reduce depressive symptoms among those in need of care. Prior research suggests that combining cognitive-behavioral therapy (CBT) and psychopharmacology can produce optimal treatment outcomes compared to the use of either treatment individually. Transcranial Magnetic Stimulation (TMS) is one promising brain stimulation approach used to treat MDD, especially among patients with treatment-resistant symptoms. Like psychopharmacological interventions, TMS may produce optimal treatment outcomes when paired with CBT. However, standard TMS protocols are time-intensive, typically requiring daily doctor visits for one hour of six to eight weeks. Therefore, an internet-delivered CBT protocol may augment the effects of TMS without substantially increasing patient burden. To that end, the present study assesses if a combined TMS and internet-delivered CBT protocol may produce superior treatment outcomes compared with TMS alone.

Eligibility Criteria

Inclusion Criteria

Subjects with Major Depressive Disorder who are receiving a full course of TMS treatment in at the UCLA TMS Clinic. Eligibility is determined by TMS physicians who are co-investigators on this study.

Exclusion Criteria

Any indications of metal implants, pregnancy, psychosis, autism spectrum disorders, complex regional pain syndromes, substance use dependence and comorbidities that would interfere with treatment response. The criteria are assessed using MINI interview and Hamilton Depression scale conducted by trained and certified interviewers. Participants may not participate if they are currently completing CBT outside of the study.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05988619). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.