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N/A N=92 Randomized Single-blind Treatment

Frequency vs Error Augmentation Training in Acute Physical Therapy Post Stroke

Stroke · Stroke, Acute · Stroke, Ischemic

Enrolled (actual)
92
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcome: Primary: Change in Postural Assessment Stroke Scale (PASS) — 19.64; 19.86; 19.25; 23.21 score on a scale

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Frequent PT (Behavioral); Intense PT (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Medical University of South Carolina
Primary completion
Mar 2025

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Postural Assessment Stroke Scale (PASS)
19.64; 19.86; 19.25; 23.21; 22.95; 27
PRIMARY
Change in Activity Measure for Post Acute Care (AM-PAC)
15.32; 15.32; 14.79; 16.83; 17.32; 19.26
SECONDARY
Patient's Modified Rankin Scale (mRS) Post Acute Stroke
0; 0; 0; 0; 1; 2
SECONDARY
Change in National Institute of Health Stroke Scale Score (NIHSS)
8.4; 7.38; 7.25; 7.13; 6.11; 5.84
SECONDARY
Length of Stay
6.20; 6.09; 6.75; 5.96

Summary

The Department of Physical Therapy in conjunction with the Comprehensive Stroke Center at the Medical University of South Carolina (MUSC) seeks support for developing an evidence-based approach for the mobilization of patients within the first 24 hours of admission for an acute stroke and for increasing the frequency and intensity of acute PT services while inpatient. This evidence will prepare physical therapists and guide practice in the delivery of acute stroke mobilization in the hospital setting to optimize length of stay, disposition planning, and enhance long term recovery outcomes. This research hopes to challenge the clinical paradigm regarding the possibility of decreased functional outcomes with early mobilization post stroke. The investigators acknowledge that acute stroke patients may not be able to tolerate an extensive early mobility program but may benefit from shorter more frequent sessions of therapy early in their recovery. Throughout the literature, there are clinical practice guidelines for both the inpatient rehabilitation and outpatient therapy sectors and post stroke recovery. Little is known about the contribution of therapy services in the acute hospital setting and therapy's impact on long term functional gains. This study will compare outcomes (AM-PAC, PASS, length of stay and post discharge mRS) across four groups- 1) standard of care 2) increased frequency 3) increased intensity 4) combined increased frequency and intensity. The goal of this project is to determine the appropriate dosage of post stroke mobility in the acute care hospital setting.

Eligibility Criteria

Inclusion Criteria

  • Acute stroke
  • NIHSS score of 2-18 with motor involvement
  • Age 18-80
  • Medical stability for increased therapy services, determined by Stroke Service NP (no large fluctuations or instability for vitals, BP, mental status or seizure like activity) Ability to provide informed consent (alert and oriented x 4 and able to follow commands)

Exclusion Criteria

  • Medical instability or cerebral perfusion dependence, requiring bed rest
  • Pregnancy (noted in chart)
  • Inmates (noted in chart or by guards present at bedside)
  • Known current COVID-19 infection (PCR positive labs)
  • Dialysis (noted in chart & performed while inpatient)
  • External Carotid Artery Stenting Procedure
  • Hemorrhagic Stroke
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT06042179). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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