N/A
N=21
Compassion-Based Resiliency Training (CBRT) Intervention on Racism-based Stress
Racism · Stress, Psychological
Bottom Line
View on ClinicalTrials.gov: NCT06146218 ↗Enrolled (actual)
21
Serious AEs
4.8%
Results posted
Apr 2026
Primary outcome: Primary: Feasibility of Study — 19 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Contemplative-Based Resilience Training (CBRT) (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Rockefeller University
- Primary completion
- Aug 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Feasibility of Study |
19 | — |
| PRIMARY Acceptability of CBRT (Qualitative Interview Findings) |
6; 17; 11; 5; 12 | — |
| SECONDARY Allostatic Load Composite Score (NHANES Clinically Relevant Scoring 0-11 ) |
2.11; 2 | 0.135 |
| SECONDARY Cortisol Awakening Response (CAR) |
.100; -0.025 | 0.395 |
| SECONDARY Composite CTRA Gene Expression Score |
6.20; 6.19 | 0.93 |
| SECONDARY Telomere Length |
— | — |
Summary
The primary aim of this study is to explore the feasibility, acceptability, and preliminary effectiveness of CBRT intervention among African Americans compared to a wait-list control group. The specific objectives include assessing feasibility, gathering participant feedback, evaluating CBRT's impact on psychological and biological outcomes, and exploring the mediating role of mindfulness.
The study is a 1-group pretest-posttest design. 20 African American participants will be recruited from various sources and undergo baseline and follow-up assessments. The intervention involves a 10-week CBRT program focusing on mindfulness, compassion, self-awareness, and stress-reduction techniques. Measures include sociodemographics and psychological measures (race-based stress, depression, perceived stress, quality of life, social connectedness, sleep, and resilience) and biological measures ( allostatic load, saliva cortisol, telomere length, and gene expression. Data is collected at baseline and 10 weeks.
Eligibility Criteria
Inclusion Criteria
- Self Identity as African American or Black
- 18-50 years old
- Fluent in English
Exclusion Criteria
- History of significant pre-existing brain disease or injury (e.g., dementia, stroke, seizure disorder, and head injury with cognitive sequelae or loss of consciousness more than 30 minutes, seizure disorder)
- Reported history of learning disability/mental retardation
- Current Attention Deficit Hyperactive Disorder (ADHD), depression, bipolar disorder, post-traumatic stress disorder (PTSD), or psychotic disorder diagnosis
- Current psychotropic medication (as these medications are known impacts on brain function) e.g. antipsychotics, antianxiety
- Severe/chronic medical illness (e.g., reported HIV+ status, cardiovascular disease, liver disease/cirrhosis, chronic kidney disease, current/past cancer with radiation/chemotherapy treatment, etc.)
- Current methadone/suboxone/buprenorphine (or similar) maintenance
- Use of illicit substances other than cannabis within the past 90 days
- Pregnant
- Major life events in the last 30 days (hospitalization, marriage, death in the family of friends, disaster)
Data sourced from ClinicalTrials.gov (NCT06146218). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.