TheraPAP Equivalence Crossover Study

Inclusion Criteria

• AHI > 10 on a previous PSG.
• CPAP adherence for an average of 5 h/night in the 2 months before the study
• BMI above 18 kg/m2, inclusive.

Exclusion Criteria

• Current clinically significant sleep disorder other than OSA of a severity that would interfere with study participation or interpretability of data (including central sleep apnea, per central AHI > 5 events/h).
• Current clinically unstable cardiac disease (e.g., rhythm disturbances, coronary artery disease or cardiac failure) or poorly controlled hypertension (>140/90mmHg).
• Current clinically significant neurological disorder, including epilepsy/convulsions.
• Other serious major organ system disease including renal failure, lung disease, neuromuscular disease, or liver disease.
• Schizophrenia, schizoaffective disorder or bipolar disorder according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM 5) or International Classification of Disease tenth edition criteria.
• Attempted suicide within 1 year prior to screening, or current suicidal ideation.
• History of substance use disorder as defined in DSM-V within 24 months prior to Screening Visit.
• A serious illness or infection in the past 30 days as determined by investigator.
• Clinically significant cognitive dysfunction as determined by investigator.
• Chronic oxygen therapy.
• Patients with hypoglossal nerve stimulation implant.
• Any non-previously mentioned vulnerable population.
• Any condition that in the investigator's opinion would present an unreasonable risk to the participant, or which would interfere with their participation in the study or confound study interpretation.