N/A
Completed N=277
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
Source: ClinicalTrials.gov NCT06272994 ↗Enrolled (actual)
277
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcomePrimary: Vancomycin-free Hours Alive — 105.7; 109.7 Hours
Summary
This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Vancomycin-free Hours Alive |
105.7; 109.7 | — |
| SECONDARY Time Alive Off Vancomycin |
128; 138 | — |
| SECONDARY 30-day All-cause Mortality |
56; 31 | — |
Eligibility Criteria
Inclusion Criteria
- Adult (age greater than or equal to 18) patients admitted/transferred to the Vanderbilt University Medical Center (VUMC) Medical Intensive Care Unit (MICU) from the VUMC Emergency Department or from a hospital floor within 48 hours of admission.
- Suspicion for pneumonia on admission (defined as an indication for antibiotics of "respiratory infection" and/or an order for a respiratory culture i.e., sputum culture, tracheal aspirate culture, or bronchoalveolar lavage (BAL) culture).
- No topical nasal decolonization during hospitalization prior to collection of MRSA nasal swab PCR.
- Must match both of the following in either order:
- The patient has been admitted to and physically located in the MICU.
- The patient has received a continuing vancomycin order, or a pharmacokinetics consult for a continuing vancomycin order, no later than 24 hours following their physical admission to the MICU.
Exclusion Criteria
- Hospital stay of longer than 48 hours prior to MICU admission.
- Known to be a prisoner
Data sourced from ClinicalTrials.gov (NCT06272994). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.