N/A
Completed N=30
Personalized Attention-Deficit/Hyperactivity Disorder (ADHD) Medication Experiment Study
Attention Deficit Hyperactivity Disorder
Source: ClinicalTrials.gov NCT06305078 ↗
Enrolled (actual)
30
Serious AEs
0.0%
Results posted
May 2026
Primary outcomePrimary: Decision Making Involvement Scale [Parent Seek] - Reported by Child — 2.6; 2.9 Scores on a Scale — p=<0.03
Summary
The primary goal of the project is to test personalized medication experiments to inform decisions about future medication use. Our central hypothesis is that our intervention will lead to within subject increases in adolescent involvement in decision making and decreases in uncertainty about future medication use. The investigators view this open label trial as a pilot study to test the feasibility, acceptability, and preliminary efficacy of the medication experiment intervention and therefore warrants further testing in a future larger trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Decision Making Involvement Scale [Parent Seek] - Reported by Child |
2.6; 2.9 | <0.03 sig |
| PRIMARY Decision Making Involvement Scale [Parent Seek] - Parent Report |
2.6; 2.6 | <0.48 |
| PRIMARY Decision Making Involvement Scale [Child Express] - Child Report |
2.4; 2.5 | <0.28 |
| PRIMARY Decision Making Involvement Scale [Child Express] - Parent Report |
2.5; 2.3 | <0.79 |
| PRIMARY Decisional Conflict - Parent Report |
15.9; 9.3 | <0.12 |
| PRIMARY Decisional Conflict - Child Report |
26.3; 22.5 | <0.01 sig |
| PRIMARY Decision Making Involvement Scale - Joint/Options |
2.4; 2.0; 2.5; 2.5 | <0.45 |
| PRIMARY Decision Making Involvement Scale - Child Express |
3.0; 2.3 | <0.01 sig |
| SECONDARY Difference in Intention to Give/Take Medication on School Days |
1; 0 | 0.07 |
| SECONDARY Difference in Intention to Give/Take Medication on Weekend Days |
1; 1 | .61 |
| SECONDARY Difference in Intention to Give/Take Medication on School Vacation Days |
1; 1 | 0.35 |
| SECONDARY System Usability Scale Total Score |
84.2; 69.4 | — |
| SECONDARY Implementation of Decision |
25; 5 | — |
Eligibility Criteria
Inclusion Criteria: Participants for the study must meet all of the following criteria:
- Consent: A parent or legal guardian must provide written informed consent
- Assent: Adolescents must provide written assent to participate in the study
- Ages 11-15
- Treated for ADHD by pediatrician
- First prescribed ADHD medicine more than one year prior to enrollment
- Filled at least one prescription for a stimulant medication in the past year
- Uncertainty about continued ADHD medication use
- Only one child per household can participate in the study. For families who have more than one child who is potentially eligible, they may decide which of their children would be the best fit for the study.
Exclusion Criteria: Exclusion Criteria: Participants will be excluded from the study if they meet any of the following criteria:
- Do not have reliable access to the internet at their home or another location.
- Will not permit their child to access the internet for study related activities.
- Are not able or willing to send or receive text messages.
Data sourced from ClinicalTrials.gov (NCT06305078). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.