N/A
Completed N=39
Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology
Source: ClinicalTrials.gov NCT06445712 ↗Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcomePrimary: Pain Tolerance — 44.72; 45.09 seconds
Summary
The goal of this study is to investigate the role of physical pain in the link between childhood adversity and later psychopathology. Children who are participating in a larger longitudinal study will be asked to submerge their hand in cold water and hold it in the cold water as long as possible. Participants will do this twice, once alone and once holding the hand of their parent, to examine the role of parental support in pain development. The study will examine self-report of pain and salivary cortisol response to pain. It is hypothesized that children who have been exposed to more adversity will experience increased pain response and increased psychopathology symptoms. It is expected that higher social support in the family will decrease this relationship.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Tolerance |
44.72; 45.09 | — |
| PRIMARY Pain Sensitivity |
5.87; 5.13 | — |
Eligibility Criteria
Inclusion Criteria
- Subjects who have been enrolled in our ongoing CARE study
Exclusion Criteria
- Subjects who have not participated in the CARE study
Data sourced from ClinicalTrials.gov (NCT06445712). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.