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Home › Conditions › Child Development

Child Development

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Child Development

19 trials tracked for Child Development: 5 in phase 3 or 4 and 3 with published results. The most-cited published study has 61 citations.

19Trials tracked
5Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 3 Phase 3 2 Other / NA 14
  1. Phase 4 Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso Completed · 61 cited
  2. Phase 4 Preemie Tots: A Pilot Study to Understand the Effects of Prematurity in Toddlerhood Completed · 58 cited
  3. Phase 4 Omega Tots: A Randomized, Controlled Trial of Long-chain Polyunsaturated Fatty Acid Supplementation of Toddler Diets and Developmental Outcomes Completed · 45 cited
  4. Phase 3 MOM Program 8-Year Follow-up Completed
  5. Phase 3 The MOM Program: 5 Year Follow-up Study of a Home Visiting Program at The Children's Hospital of Philadelphia Completed
  6. N/A Testing the Effectiveness of Telephone-based Early Childhood Developmental Screening Completed
Show 13 more trials
  1. N/A Resident Surveillance of Pediatric Patient Developmental Status at the Two Month Preventive Care Visit Completed
  2. N/A Added Sugar Intake and Brain Structure and Function Completed
  3. N/A Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology Completed
  4. N/A An Intervention to Improve Motor Skills in Young Children Completed
  5. N/A Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families Completed
  6. N/A Achieving My Potential: A Randomized, Controlled Trial of a Telephone-Based Developmental Care Coordination System Completed
  7. N/A Promoting Resilience and Lowering Risk in Early Childhood Completed
  8. N/A Pathways for Parents After Incarceration Feasibility Study Completed
  9. N/A Early Childhood Outside (ECO) - Randomized Controlled Trial Study Completed
  10. N/A Early Literacy Promotion Intervention Completed
  11. N/A Room to Grow Evaluation for Children Completed
  12. N/A The Opening Doors to Early Intervention Study Completed
  13. N/A School-Based Mental Health Effectiveness Study Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Child Development: what the trials found

In established trials, home visiting programs showed mixed effects on child development outcomes. The MOM Program home visiting did not significantly improve cognitive or academic scores at age 5 (Woodcock-Johnson Cognitive Ability Test: 89.32 vs 87.62, p=0.39; Broad Reading: 90.92 vs 90.94, p=.99; Broad Math: 94.30 vs 90.80, p=0.16) 6. Similarly, a professional support home visiting model found no significant difference in IQ (WPPSI-III: 86.5 vs 87.4, p=0.59) or internalizing behavior (8% vs 11%, p=0.72), but did show a significant reduction in externalizing behavior problems (3% vs 12%, p<0.01) 7.

Regarding nutritional supplements, LCPUFA oil supplementation did not significantly affect child behavior outcomes, including Pervasive Developmental Disorders Screening Test-II Stage 2 (-1.0 vs -0.2, p=0.67) and BITSEA scores (p=0.22) 4. DHA+AA supplementation significantly altered erythrocyte fatty acid levels (p<0.001) but did not significantly affect infant behavior as measured by the IBQ-R (p=.13) 5.

Azithromycin was studied in a phase 4 trial (N=252) but no specific outcome data were provided for child development 3.

Recent results — preliminary, needs further review

  • A recent trial of a parenting intervention (N=322) reported mean depressive symptoms (CES-D) ranging from 4.17 to 5.95, perceived stress (PSS) from 4.71 to 6.21, and parental sense of competence (PSOC) from 17.01 to 18.27 across time points 1.
  • An mHealth intervention (N=24) significantly increased positive parenting activity engagement (3.75 vs 2.38, p<0.01) but did not significantly affect time spent with child daily (2.82 vs 2.72 hours, p=0.14) or Alabama Parenting Questionnaire scores (47.6 vs 47.6, p<1.00) 8.
  • A healthcare provider referral to a tax filing app (N=21) reported that 8 parents filed taxes at 3 and 9 months, and 8 had positive depression scores at baseline 9.
  • ParentCorps-Professional Development (N=2444) showed teacher knowledge scores of 41.91, 45.12, and 36.75; emotion support strategy use scores of 4.14, 4.19, and 3.98; and teacher stress scores of 1.84, 1.83, and 1.83 across groups 10.
  • A trial of parental support cold pressor task (N=39) and another with N=42 are recent but no outcome data were provided 211.

For the clinician treating this condition

  • Home visiting programs may reduce externalizing behavior problems but have not shown consistent benefits on cognitive or academic outcomes.
  • Nutritional supplements like LCPUFA or DHA+AA do not appear to improve child behavior or development in these trials.
  • Recent mHealth and parenting interventions show promise for improving positive parenting practices, but larger studies are needed.

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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