N/A N=30 Randomized Single-blind Treatment

Pharmacopuncture Therapy for Chronic Knee Pain

Chronic Knee Pain

Bottom Line

View on ClinicalTrials.gov: NCT06505681 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2026

Primary outcome: Primary: Knee Pain Numeric Rating Scale, NRS — 3.15; 5.20 scores on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Pharmacopuncture (Procedure); Physical therapy (Procedure)
Age: Adult, Older Adult · 19+ yrs
Sex: All
Sponsor: Jaseng Medical Foundation
Primary completion: Jul 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Knee Pain Numeric Rating Scale, NRS	3.15; 5.20	—
SECONDARY Knee Pain Visual Analogue Scale, VAS	30.63; 52.22	—
SECONDARY Range of Motion, ROM	135; 135; 0; 0; 5; 5	—
SECONDARY Korean Western Ontario & McMaster, K-WOMAC	43.02; 56.18	—
SECONDARY Short Form-12 Health Survey Version 2, SF-12 v2	53.27; 51.89	—
SECONDARY EuroQol-5 Dimension, EQ-5D-5L	0.81; 0.78	—
SECONDARY Patient Global Impression of Change, PGIC	2; 3	—
SECONDARY Credibility and Expectancy	8; 7	—
SECONDARY Economic Evaluation Question-Medical Costs	500,000; 400,000	—
SECONDARY Economic Evaluation Question-Time Cost	120,000; 110,000	—
SECONDARY Economic Evaluation Question-Productivity Loss	600,000; 500,000	—

Summary

This study is a pragmatic randomized controlled trial. Condition/disease: Chronic Knee Pain. Intervention: Pharmacopuncture

Eligibility Criteria

Inclusion Criteria

Patients whose NRS (Numeric Rating Scale) of knee pain is 5 or higher
Patients whose symptoms persist for more than 3 months
Patients who are between 19 and 70 years of age
Patients who, after receiving a detailed explanation of the clinical study and fully understanding it, voluntarily decide to participate and agree in writing to comply with the precautions.

Exclusion Criteria

Patients who have been diagnosed with a specific serious disease that may cause knee pain (acute fracture, dislocation, traumatic damage to ligaments and cartilage, etc.)
If the cause of the pain is caused by a disease other than the knee (tumor, fibromyalgia, rheumatoid arthritis, gout, lumbar disc herniation, etc.)
Cases that occur due to a traumatic event and require surgical intervention due to suspected acute fracture, dislocation, ligament and cartilage damage
Patients who diagnosed other chronic diseases (stroke, myocardial infarction, kidney disease, diabetic neuropathy, dementia, epilepsy, etc.) that may interfere with the treatment effect or interpretation of results.
Patients who are currently taking steroids, immunosuppressants, drugs for mental illness, or other drugs that may affect the results of the study
Patients who acupuncture treatment is inappropriate or unsafe: Patients with bleeding disorders, those receiving anticoagulant treatment, and patients with severe diabetes at risk of infection.
Patients who have taken drugs that may affect pain, such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), or have received herbal acupuncture or physical therapy within the past week
Patients who are pregnant, planning to become pregnant, or are breastfeeding
Patients within 3 months after knee surgery or if knee replacement surgery was performed
Patients who has been less than 1 month since you finished participating in another clinical study, or if you are planning to participate in another clinical study during the study participation and follow-up period within 6 months from the date of selection
Patients who difficult to fill out the consent form for research participation
Other cases where participation in clinical research is difficult in the judgment of the researcher.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT06505681). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.