N/A N=57 Prevention

THRIVE: Culturally AdapTed Harm Reduction Intervention

Opioid Use · Stimulant Use

Bottom Line

View on ClinicalTrials.gov: NCT06609278 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2026

Primary outcome: Primary: Participant Confidence Using Harm Reduction Techniques at Baseline — 5.43; 6.61 score on a scale

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: harm reduction intervention (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Brittany Miller-Roenigk
Primary completion: Jun 2025

Outcome Measures

Outcome	Result	p-value
PRIMARY Participant Confidence Using Harm Reduction Techniques at Baseline	5.43; 6.61	—
PRIMARY Participant Confidence Using Harm Reduction Techniques Post Intervention	8.36; 8.36	—
PRIMARY Participant Willingness to Use Harm Reduction Techniques at Baseline	6.02; 7.86	—
PRIMARY Participant Willingness to Use Harm Reduction Techniques Post-intervention	8.46; 8.68	—
PRIMARY Participant Comfort to Possess Harm Reduction Techniques Baseline	7.26; 7.70	—
PRIMARY Participant Comfort to Possess Harm Reduction Techniques Post Intervention	8.70; 8.49	—
PRIMARY Participant Confidence Describing How to Use Harm Reduction Techniques to Others Baseline	6.35; 6.88	—
PRIMARY Participant Confidence Describing How to Use Harm Reduction Techniques to Others Post Intervention	8.33; 8.68	—
PRIMARY Participant Willingness to Teach Others How to Use Harm Reduction Techniques Baseline	7.25; 7.54	—
PRIMARY Participant Willingness to Teach Others How to Use Harm Reduction Techniques Post Intervention	8.44; 8.67	—
PRIMARY Change in Knowledge of How Overdose Occurs	.8; .95	—
PRIMARY Change in Perceived Knowledge/Confidence of How to Prevent and Intervene With an Overdose	1.33; 1.89	—

Summary

The goal of this study is to develop and test a culturally adapted harm reduction intervention among Black adults who misuse opioids and/or stimulants. The questions it aims to answer include: will the culturally adapted harm reduction educational intervention increase overall knowledge of overdose and prevention/intervention techniques and increase confidence and willingness to use/teach interventions to others at-risk.

Eligibility Criteria

Inclusion Criteria

Identify as Black or African American
Currently a resident of study areas
Report misuse of stimulants and/or opioids in the last six months

Exclusion Criteria

Do not identify as Black or African American
If they participated in Aim 1 of the study
Do not want to be audio-recorded

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT06609278). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.