Phase 4
N=90
Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI Outcome
Female Infertility
Bottom Line
View on ClinicalTrials.gov: NCT06684951 ↗Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Apr 2025
Primary outcome: Primary: Serum Level of TNF-alfa,IL-10, for All Participants in Three Study Group at Day of Ova Pickup Compared to That at Day of Embryo Transfer — 43.56; 41.59; 40.94; 30.33 pg/ml
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- hCG (Drug)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Omayma Ismail Khalaf
- Primary completion
- Jan 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Serum Level of TNF-alfa,IL-10, for All Participants in Three Study Group at Day of Ova Pickup Compared to That at Day of Embryo Transfer |
43.56; 41.59; 40.94; 30.33; 38.06; 42.3 | — |
| PRIMARY Ultrasound Parameter (RI,PI) |
0.49; 0.51; 0.5; 0.42; 0.48; 0.5 | — |
| PRIMARY Systole Flow/ Diastole Flow |
2.05; 2.3; 2.01; 1.87; 2.21; 1.92 | — |
| PRIMARY TNF-alfa/IL-10 Ratio |
1.89; 1.56; 1.71; 1.38; 1.66; 1.86 | — |
| SECONDARY Intra Cytoplasmic Sperm Injection Outcome |
16; 12; 8; 14; 18; 22 | — |
Summary
a number of infertile women who were prepared for ICSI and immediately post ova pick up intrauterine flushing with human chorionic gonadotropin was done to study the effect of this drug on ICSI outcome and ultrasound parameter.
Eligibility Criteria
Inclusion Criteria
- The patient's consent to participate in the research study is crucial for data collection and analysis.
- Each pair of individuals undergoing IVF/ICSI procedures typically possess grade 1 (G1) embryos during the embryo transfer process.
- The age range of the female participants varied from 18 to 40 years.
- Infertility arising from female factors, including issues like blocked fallopian tubes, lack of ovulation, and unexplained fertility challenges, was examined.
- Male-related factors contributing to infertility were also taken into consideration.
- The procedure involved the transfer of grade one embryos during a fresh cycle.
Exclusion Criteria
Endometrioses, whether clinically suspected or discovered during laparoscopy, are of interest.
- Instances of congenital abnormalities in the reproductive system are being examined.
- Individuals above the age of forty are under consideration. 4. Individuals who do not possess G1 embryos are also included. 5. Patients with chronic systemic conditions (such as diabetes, hematologic disorders, hypertension, autoimmune disorders of the connective tissue, asthma, thyroid disorders) are a part of the study.
- The presence of empty follicles is noted in stimulated cycles where no oocytes were obtained during the aspiration procedure.
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Data sourced from ClinicalTrials.gov (NCT06684951). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.