Phase 4
N=104
Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients
Hip Fractures · Analgesia · Femoral Nerve
Bottom Line
View on ClinicalTrials.gov: NCT06862154 ↗Enrolled (actual)
104
Serious AEs
2.9%
Results posted
Dec 2025
Primary outcome: Primary: Pain Score Change — 4; 2 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- IV Analgesia- Fentanyl (Drug); Femoral Nerve Block (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Marmara University
- Primary completion
- Dec 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Score Change |
4; 2 | — |
| SECONDARY Number of Participants With Adverse Events |
0; 3; 0; 5; 0; 8 | — |
| SECONDARY Number of Participants With Rescue Analgesic Use |
11; 32 | — |
Summary
It is well-established that hip fractures impose a significant medical, socioeconomic, and financial burden. In the elderly population, the associated mortality and morbidity are particularly pronounced: within one year following a hip fracture, mortality rates range from 20% to 30%; approximately one-third of patients require an elevated level of care, and only 30-40% retain the potential to fully recover and regain their pre-injury functional status. Consequently, strategies to enhance early outcomes in these patients are urgently needed. Reducing preoperative pain has been shown to improve patient satisfaction, facilitate the timing and effectiveness of physical therapy, shorten hospital stays, and support long-term functional recovery. Perioperative nerve blockade has demonstrated superior efficacy compared to systemic analgesia, traction, neurostimulation, and alternative medicine approaches. The advantages of peripheral nerve blocks include reduced pain scores, decreased opioid consumption, a lower risk of pneumonia, shorter time to ambulation, diminished postoperative cognitive dysfunction, and a more cost-effective analgesic regimen. This study seeks to evaluate the effects of femoral nerve block (FNB) on common hip fracture types within a trauma patient population. Specifically, we compared the efficacy of ultrasound-guided, single-injection femoral nerve block against prevalent hip fracture types prior to surgery, assessing outcomes longitudinally through changes in pain scores and opioid requirements.
Eligibility Criteria
Inclusion Criteria
- Age ≥18 years
- Radiologically confirmed proximal femur fracture (femoral neck or intertrochanteric fracture)
- Ability to provide informed consent or have a legal representative provide consent
Exclusion Criteria
- Hemodynamic instability (SBP 120 bpm)
- Severe trauma requiring immediate surgical intervention (e.g., multiple trauma, head injury)
- Bleeding disorders or anticoagulation therapy (INR ≥2.5, platelet count <50,000/mm³)
- Known allergy to local anesthetics (bupivacaine) or opioids (fentanyl)
- Pregnancy
- Prior administration of local anesthetic blocks or systemic opioids before arrival
- Periprosthetic fractures or previous surgery on the affected hip
Data sourced from ClinicalTrials.gov (NCT06862154). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.