Phase 4 N=4 Treatment of CNS Sarcoidosis With H.P. Acthar Gel
CNS Sarcoidosis
Primary: Karnofsky Performance Status (KPS) Score — 76.67; 76.67 score on a scale — p=1.0
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=25 HCV Positive Heart Donors
Heart Failure
Primary: Sustained Virologic Response After Treatment — 24 Participants
Phase 4 N=19 Tear Lipid Layer Thickness With Emollient Eye Drops
Dry Eye Syndromes
Primary: Change in Tear Lipid Layer Thickness — 4.8; 8.8 nm
Phase 4 N=385 Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children
Pneumonia
Primary: Desirability of Outcome Ranking (DOOR) — 97; 107; 47; 42 Participants — p=<0.001
Phase 4 N=25 Metformin for the Prevention of the Metabolic Side-effects of Zyprexa
Metabolic Complications
Primary: Weight Gain — 2.54; 5.88 kilogram
Phase 4 N=68 Sofosbuvir Based DAA Therapy in HIV/HCV Coinfected Pre or Post Liver Transplant
HIV · Hepatitis C · Cirrhosis
Primary: Number of Participants With Sustained Virologic Response (SVR) — 38; 25 Participants
Phase 4 N=30 Increased Cefazolin During Cesarean Delivery in Obese Population
Obesity · Obesity, Morbid · Pregnancy
Primary: Achievement of Minimal Inhibitory Concentrations Within Adipose and Serum Sampled at Time of Cesarean Delivery — 22.4; 9.6 mg/g
Phase 4 N=75 Sublingual Sufentanil vs Intravenous Fentanyl for Acute Pain in the Ambulatory Surgery Center
Pain · Pain, Acute · Anesthesia
Primary: Recovery Room Time — 73.0; 65.0 minutes
Phase 4 N=18 Investigating the Immunogenicity of a U.S.-Licensed Meningococcal Serogroup B Vaccine (Trumenba)
Meningococcal Infections
Primary: Breadth of Protective Activity of Serum Anti-FHbp Antibody Responses of Adults Immunized With Trumenba Vaccine as Assessed by Serum Bactericidal Titers — 93 percentage…
Phase 4 N=55 Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
Heart Failure, Diastolic · Diastolic Heart Failure · Hypertension
Primary: Coronary Flow Reserve — 2.64; 2.65; 2.06 ratio
Phase 4 N=109 Dexmedetomidine in Pediatric Tonsillectomy
Pediatric Adenotonsillectomy · Post Operative Analgesia
Primary: Amount of Post-Operative Rescue Morphine Required for Analgesia — 45.2; 37.0; 43.3; 36.5 ug/kg
Phase 4 N=40 Demonstration of Reverse Remodeling Effects of Entresto. Using Echocardiography Endocardial Surface Analysis
Heart Failure
Primary: Change From Baseline in LV Remodeling 2D End-Diastolic Diameter (cm) — 6; 6 cm — p=<0.001
Phase 4 N=80 Effect of Intraoperative Dexamethasone on Post-op Dry Eye
Dry Eye Syndromes
Primary: Evaluation of Intraoperative Use of Dexycu on Tear Film Osmolarity at 3 Weeks Postoperatively — 311.15; 316.3 mOsmol/L — p=<.01
Phase 4 N=180 IV Acetaminophen for Post-Operative Pain Management in Enhanced Recovery After Surgery (ERAS) Population
Abdominal Wall Hernia · Pancreatic Diseases · Bowel Disease
Primary: Postoperative Pain Intensity — 33; 42 Participants
Phase 4 N=19 Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease
Dry Eye Disease
Primary: Dry Eye Comfort Questionnaire, SANDE — 44.77 scores on a scale