12,372 trials
Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
Primary: Overall Response Rate (ORR) Assessed by the Investigator — 83.5; 74.2 percentage of participants — p=<0.0001
Coronavirus · Covid19
Primary: COVID-19 Symptom Duration (Phase 2) — 21.0; 18.5; 24.0; 20.5 Days
Osteoarthritis
Primary: Change in Visual Analog Pain Scale (VAS-pain) Score — -20.2; -15.9; -16.7; -25.2 units on a scale
Chronic Kidney Disease
Primary: Interventional Part: Time to First Occurrence of Kidney Disease Progression or Cardiovascular Death ('as Adjudicated') — 8.96; 6.85 patients with events/100 pt-yrs at…
Cervical Dysplasia · Cervical High Grade Squamous Intraepithelial Lesion · HSIL
Primary: Percentage of Participants With No Evidence of Cervical HSIL on Histology and No Evidence of HPV-16 and/or HPV-18 in Cervical Samples — 22.5; 11.1 percentage of…
Amyotrophic Lateral Sclerosis
Primary: Disease Progression as Assessed by the ALSFRS-R Total Score — -1.11; -1.03 ALSFRS-R total score points per month
Amyotrophic Lateral Sclerosis
Primary: Disease Progression as Assessed by the ALSFRS-R Total Score — -1.01; -1.03 ALSFRS-R total score points per month
Migraine · Migraine With Aura · Migraine Without Aura
Primary: Percentage of Subjects With Freedom From Migraine Headache Pain at 2 Hours Post Dose — 146; 124 Participants
Paroxysmal Nocturnal Hemoglobinuria
Primary: Change From Baseline in Hgb at Week 12 — 29.40; 4.96; 28.08; 4.62 g/L — p=0.0007
Acne Vulgaris
Primary: Absolute Change From Baseline in Inflammatory Lesion Counts — -13.1; -10.9 inflammatory acne lesions
Carcinoma, Hepatocellular
Primary: Progression-free Survival (PFS) Per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) — 8.2; 8.1 Months
Binge-Eating Disorder
Primary: Change in Binge Eating Frequency — 6.4; 5.4 binge-eating episodes per month — p=.44
Critical COVID-19 With Respiratory Failure · Acute Respiratory Distress Syndrome (ARDS) · Corona Virus Infection
Primary: Resolution of Respiratory Failure (Alive and Free of Respiratory Failure) — 72; 33 Participants
Chronic Obstructive Pulmonary Disease
Primary: Least Square (LS) Mean Change From Baseline in Average Forced Expiratory Volume in 1 Second (FEV1) Area Under the Curve Over 12 Hours (AUC0-12h) at Week 12 — 0.0480…
Painful Diabetic Neuropathy
Primary: Percentage of Subjects With Adverse Events (AE) Reported Spontaneously by the Subject or Observed by the Investigator — 80.9 percentage of participants