Phase 4 N=643 A Multi-site Randomized Controlled Trial Comparing Regional and General Anesthesia for Effects on Neurodevelopmental Outcome and Apnea in Infants
Inguinal Hernia
Primary: Full Scale IQ Score — 100.5; 100.1 score on scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=64 High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase
Hip Dysplasia · Postoperative Complications
Primary: Number of Participants With Moderate to Severe Postoperative Pain — 26; 22 Participants — p=0.248
Phase 4 N=88 Monoamine Contributions to Neurocircuitry in Eating Disorders
Eating Disorder
Primary: 5-HT Transporter Binding as Measured During the PET Scan — 1.68; 1.54; 1.46; 1.60 binding potential (BPND) — p=> 0.05
Phase 4 N=73 Direct Application of Systane Complete to Contact Lenses
Dry Eye · Contact Lens Complication
Primary: Difference in Ocular Surface Damage as Measured by the Brien Holden Vision Institute (BHVI Grading Scale) at Two Weeks — 0.44; 1.08; 0.83 Score on a Scale — p=0.30
Phase 4 N=287 Clinical Trial of Efficacy and Safety of Ergoferon in the Treatment of Acute Respiratory Viral Infections in Children
Acute Respiratory Viral Infections
Primary: Time to Alleviation of All ARVI Symptoms. — 4.5; 5.2 days — p=0.026
Phase 4 N=312 A Study Comparing the Dulaglutide Pen and the Semaglutide Pen
Diabetes Mellitus, Type 2
Primary: Participant Preference Between 2 Injection Devices Based on Global Preference Item — 87.7; 80.6; 2.6; 4.5 percentage of participants — p=<0.0001
Phase 4 N=7 Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans
Human Microbiome
Primary: Change in the Abundance of Staphylococcus Aureus in the Nose After Decolonization — -4174 fg/uL
Phase 4 N=800 A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive
Primary: Change From Baseline in Trough Forced Expiratory Volume in 1 Second (FEV1) on Day 85 — 0.115; 0.020 Liters — p=<0.001
Phase 4 N=853 Efficacy of Diosmectite (Smecta®) in the Symptomatic Treatment of Acute Diarrhoea in Adults
Acute Diarrhoea
Primary: Time to Recovery — 66.0; 68.6 Hours — p==0.2524
Phase 4 N=100 A Study of Epoetin Beta Treatment in Anemic Participants With Myelodysplastic Syndrome (MDS)
Myelodysplastic Syndromes
Primary: Proportion of Participants Achieving Erythroid Response at Week 12 as Assessed by International Working Group (IWG) 2006 Response Criteria — 60 Participants
Phase 4 N=19 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)
Juvenile Idiopathic Arthritis
Primary: Juvenile Arthritis Disease Activity Score (JADAS-71) — 0.60; 0.21; 0.00; 0.35 score on a scale
Phase 4 N=74 Clinical Study of Generic and Brand Bupropion in Depression
Major Depressive Disorder
Primary: Area Under the Curve (AUC0-24) Ratio for Racemic Bupropion — .84; .88; .83; .89 percentage of Brand — p=<0.05
Phase 4 N=25 Effects of Intravitreal Ranibizumab for Macular Edema With Nonproliferative Diabetic Retinopathy
Nonproliferative Diabetic Retinopathy
Primary: The Best Corrected Visual Acuity (BCVA) — 67.6; 76.36 letters — p=<0.0001
Phase 4 N=81 Intrathecal Morphine Versus Epidural Extended Release Morphine for Pediatric Patients Undergoing Spinal Fusion
Pain Management · Spinal Fusion · Scoliosis
Primary: Total IV Morphine Consumption up to 48 Hours Post Surgery — 34.0; 42.2 mg — p=.27
Phase 4 N=25 Study of Naltrexone-Induced Blockade of Antidepressant Effects
Depression · Major Depressive Disorder
Primary: BOLD Responses in the rACC Cortex During the Processing of Contextual Cues at Baseline (Post-placebo) — 0.47 BOLD signal — p=0.01