N/A N=941 Sertraline Pediatric Registry for the Evaluation of Safety (SPRITES)
Obsessive Compulsive Disorder
Primary: Change From Baseline in Cognitive Function Using Trails B at Month 3 — 1.03; 1.23; 0.61; -0.39 Z-score
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=121 Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia
Staphylococcus Aureus Bacteremia · Staphylococcus Aureus Endocarditis
Primary: Incidence of Adverse Events [Safety and Tolerability] — 48; 30; 64; 40 Participants
Phase 2 N=45 Trial of Ra-223 Dichloride in Combination With Hormonal Therapy and Denosumab in the Treatment of Patients With Hormone-Positive Bone-Dominant Metastatic Breast Cancer
Breast Cancer
Primary: Number of Participants With Disease Control Rate at 9 Months — 35 Participants
Phase 1 N=61 A Phase I Trial of Vandetanib (AZD6474) and Selumetinib (AZD6244) for Solid Tumours Including Non Small Cell Lung Cancer (VanSel-1)
Cancer · Non Small Cell Lung Cancer
Primary: Number of Serious Adverse Events, Non-serious Adverse Events and Treatment Emergent Adverse Events. — 10; 11; 13; 5 Adverse events
N/A N=163 EZ-blocker Versus Left Sided Double Lumen Tube in Adult Patients for Thoracic Surgery
Thoracic Injuries
Primary: Number of Double Lumen Tube (DLT) or Bronchial Blocker (BB) Replacements — 13; 14; 14; 13 Number of replacements
N/A N=16 Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
Dental Caries
Primary: Change in Mineral Density Determined by the Canary Caries Detection System — 23.424; 31.125; 35.563 Canary Number — p=0.0003
Phase 2 N=22 A Study in Patients With Mild or Moderate Ulcerative Colitis Who Take a TNF Inhibitor. The Study Investigates Whether Bowel Inflammation Improves When Patients Take BI 655130 in Addition to Their Current Therapy
Colitis, Ulcerative
Primary: Proportion of Participants With Endoscopic Improvement (MCS mESS ≤1) at Week 12 — 0.375; 0.143 Proportion of participants
N/A N=47 Evaluation of Vitamin D in Women With PCOS and Sexual Dysfunction
Female Sexual Dysfunction · Polycystic Ovary Syndrome
Primary: Sexual Function — 24.8; 26.0 score on a scale — p=0.71
N/A N=160 Success Rate of 4 Injection Protocols for Mandibular First Molars With Symptomatic Irreversible Pulpitis
Root Canal Infection
Primary: Number of Participants With Successful Injection Technique Assessed by Verbal Rating Scale (VRS) — 16; 37; 29; 26 Participants
Phase 2 N=52 Ibudilast and Withdrawal-Related Dysphoria
Alcohol Use Disorder
Primary: Negative Affect — 2.91; 2.47 units — p=.62
Phase 4 N=221 Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed
Pain
Primary: Sum of Pain Intensity Difference Over 12 Hours (SPID 0-12) — 53.20; 38.39; 13.57 Scores on a scale*hours — p=0.001
N/A N=62 Social Connections and Late Life Suicide
Depression · Suicidal Ideation
Primary: Social Connectedness — 4.33; 4.30; 0.77; 0.82 score on scale — p=.278
Phase 3 N=170 Safety and Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder
Tourette's Disorder
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs), Serious TEAEs, Severe TEAEs and TEAEs Leading Treatment Discontinuation — 5; 8; 6; 104 Participants
Phase 3 N=22 Effects of Sodium Pyruvate Nasal Spray in COVID-19 Long Haulers.
Long COVID
Primary: Change in the Symptoms of Long COVID-19 Patients — 20.33; 27; 15.71; 22.43 units on a scale — p=0.200
N/A N=102 Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan
Small Fiber Neuropathy · Fabry Disease · Ehlers Danlos Syndrome
Primary: Number of Patients With Abnormal Electrochemical Skin Conductance in the Different Study Groups Who Have Clinical Symptoms Consistent With Small Fiber Polyneuropathy…