12,372 trials
Complicated Urinary Tract Infection · Acute Pyelonephritis · cUTI
Primary: Proportion of Patients Who Achieve Composite Clinical and Microbiological Success at TOC (Test of Cure Visit) in the Microbiological Modified Intent-to-Treat (m-MITT)…
Tourette Disorder
Primary: Time From Randomization to Relapse in Participants Greater Than and Equal to (>=) 6 and Less Than (<) 18 Years During the Double-Blind R/WD — NA; 4.0 weeks
Diabetic Retinopathy
Primary: Percentage of Participants With a ≥2-Step Improvement From Baseline on the Early Treatment Diabetic Retinopathy Study-Diabetic Retinopathy Severity Scale (ETDRS-DRSS) at…
PCOS · Adolescent Obesity · NAFLD
Primary: Change in Hepatic Fat Fraction — -1.41; -1.84 Change in percentage of liver fat
Postoperative Urinary Retention · Sacrospinous Vaginal Vault Suspension · Reconstructive Pelvic Surgery
Primary: Number of Participants With Postoperative Urinary Retention — 11 Participants
Prurigo Nodularis
Primary: WI-NRS4 Response at Week 12 — 36.2; 40.0 percentage of participants — p=0.5859
Influenza
Primary: Efficacy of an Investigational Vero Cell-derived Influenza Vaccine to Prevent Infection With an Influenza Virus That is Antigenically Similar to One of the Three Strains…
Parkinson Disease
Primary: Change From Baseline in the Movement Disorder Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Parts II and III Combined Score — -1.2; -10.3 score on a…
Alopecia Areata
Primary: Number of Participants With Adverse Events as a Measure of Safety — 308; 224 Participants
Schizophrenia
Primary: Change From Baseline in Positive and Negative Syndrome Scale (PANSS) Total Scores at Week 5 of the Double-Blind Period — -16.9; -7.7 Score on a Scale — p=0.0014
Asthma
Primary: Main Study: Number of Participants With Any Treatment-Emergent Adverse Events (TEAEs) — 85; 147 Participants
Chronic Spontaneous Urticaria
Primary: Serum Concentration of Dupilumab at Weeks 12 and 24 — 67700; 105000; 45800; 91600 nanogram/milliliter
Pyruvate Kinase Deficiency
Primary: All Cohorts: Number of Participants With at Least One Treatment Emergent Adverse Events (TEAEs), Serious TEAEs, Related TEAEs and TEAEs With Severity Greater Than or…
Ichthyosis
Primary: Change in Investigator Global Assessment (IGA) Score — 41.4; 44.9 percentage of responders — p=0.39
Acute Pain
Primary: Compared the Summed Pain Intensity From the End of Surgery to 48 Hours (SPI48) Between the High-dose XG005 Group and the Placebo Group Postoperatively. — 132.63; 285.99…