Phase 4 N=6 Switch From Calcineurin Inhibitor to Belatacept in Pancreas Transplant Recipients
Nephrotoxicity
Primary: Change From Baseline in Serum Estimated Glomerular Filtration Rate (eGFR) — 2.25 ml/min/1.73m2
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=31 The Effects of Renin Inhibition on Fibrinolytic Balance and Endothelial Function
High Blood Pressure
Primary: Difference in Peak Plasma PAI-1 Level
Phase 4 N=221 Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulation With Azelaic Acid Formulation in the Treatment of Acne Vulgaris
Acne Vulgaris
Primary: Percentage Change From Baseline (Day 1) of Inflammatory Lesion (IL) Count at Week 4 - Superiority Analysis — -51.9; -38.1 Percent change — p=0.0004
Phase 4 N=72 Intra-operative Digital vs. Standard Mammography
Breast Cancer
Primary: Comparison of Operative Time Savings — 48.5; 54; 68; 74 Minutes — p=0.716
Phase 4 N=179 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate
Sinusitis
Primary: Subjective Improvement - Day 3 (Rating of "a Lot Better" or "no Symptoms") — 33; 31; 22; 33 Participants
Phase 4 N=14 Stress Cardiac MRI for Evaluation of Nonspecific Allograft Dysfunction
Heart Transplant · Acute Graft Rejection · Chronic Graft Rejection
Primary: Myocardial Perfusion Reserve — 1.52; 1.94 arbitrary units
Phase 4 N=118 Dropless vs. Standard Drops Contralateral Eye Study
Cataract
Primary: Change From Baseline (Preoperative Exam) in Macular Thickness — 12.34; 10.96; 9.84 Microns
Phase 4 N=77 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery
Retinal Detachment
Primary: Adequate Sedation Via Bispectral Index Score (BIS)and University of Michigan Sedation Scale (UMSS) — 84.8; 88; .90; .94 units on a scale — p=0.04
Phase 4 N=82 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010
Influenza
Primary: Number of Individual Twins Who Received Influenza Vaccine — 16; 14; 10; 20 Participants
Phase 4 N=84 Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
Borderline Personality Disorder · Suicide
Primary: Suicide Events — 12; 4 suicide events
Phase 4 N=199 A Non-inferiority Study to Evaluate Efficacy, Safety and Tolerability of NEUMOTEROL® 400 and SYMBICORT® Forte in Adults With Asthma
Asthma
Primary: Change From Baseline (BL) in Trough Morning Forced Expiratory Volume in One Second (FEV1) at Day (D)29 — 0.194; 0.150 Litre (L)
Phase 4 N=181 A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
Malaria
Primary: The Proportion of Adverse and Serious Adverse Events Following Unsupervised Primaquine Treatment — 0; 0; 0 events
Phase 4 N=4,730 A Toolbox Approach to Obesity Treatment in Primary Care
Obesity
Primary: Percentage of Participants Who Achieved >5% Weight Loss at 12 Months — 34.5; 15.7 percentage of participants — p=<0.001
Phase 4 N=42 Clopidogrel Versus Ticagrelor in Type-2 Diabetes
Coronary Artery Disease · Diabetes Mellitus
Primary: Flow-mediated Dilation of the Brachial Artery — 16.6; 11.6 FMD (%)
Phase 4 N=10 Transdermal Patch CVD 1000: The Effect of Heat on Nicotine Release From Nicotine Patches in Adult Smokers
Smoking
Primary: Measurement of Maximum Serum Concentration (Cmax) — 27.47; 21.32; 28.04; 22.96 ng/mL