Phase 3 N=194 Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain
Acute Pain
Primary: Change in Pain Intensity — 3.3; 3.8 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=251 Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy
Infection · Pregnancy
Primary: Count of Participants With Positive Group B Streptococcus Rectovaginal Colonization Status at 35- 37 Weeks' Gestational Age — 20; 23 Participants — p=0.87
Phase 4 N=38 Correlation of Soluble Suppression of Tumorigenicity 2 (ST2) With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022).
Colitis, Ulcerative
Primary: Serum ST2 Level at Week 6 — 21.8 ng/mL
Phase 1 N=72 A Study to Assess the Safety, Reactogenicity and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' RSV Investigational Vaccine (ChAd155-RSV) (GSK3389245A) in Healthy Adults
Respiratory Synctial Virus Infections
Primary: Number of Subjects With Solicited Local Symptoms — 2; 23; 1; 15 Participants
Phase 1 N=37 A Study To Examine The Safety, Tolerability And Pharmacokinetics Of PF-02545920 In Psychiatrically Stable Subjects With Schizophrenia
Schizophrenia
Primary: Change From Baseline in Abbreviated Extrapyramidal Symptom Rating Scale (ESRS-A) Scores (Cohorts 1 and 2) at Day 10 — -0.2; -0.3; 0.1; 0.0 Units on a scale
N/A N=204 The Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity (DH)
Dentin Sensitivity
Primary: Change From Baseline in Schiff Sensitivity Score on Day 3 — -1.37; -0.45 score on a scale — p=<.0001
Phase 1 N=35 RDEA3170 Tablet and Capsule Bioavailability Study
Healthy
Primary: Maximum Observed Plasma Concentration (Cmax) — 14.9; 23.4; 12.9; 14.0 ng/mL
Phase 3 N=108 Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens
Complications of Bone Marrow Transplant · Hematologic Neoplasms
Primary: Overall Percentage of Patients Who Had a Complete Response — 13; 28 Participants — p=0.003
Phase 2 N=298 Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain
Acute Pain
Primary: Number of Participants Requiring Naloxone — 0 Participants
Phase 4 N=638 A Study Comparing the Efficacy and Safety of the Morning Injection of Toujeo Versus Lantus in Patients With Type 1 Diabetes Mellitus
Type 1 Diabetes Mellitus
Primary: Percentage of Time of Mean Glucose Concentration Within the Target Range of 70-180 mg/dL as Obtained From CGM — 55.40; 55.18 percentage of time — p=0.8494
N/A N=756 Engagement to Care South Africa
HIV
Primary: Linkage to Care - Participants Who Received Cluster of Differentiation 4 (CD4) T-cell Count Test Result Within 3 Months of Testing HIV-positive (Binary) — 80; 121; 119…
Phase 1 N=30 Sirolimus as Therapeutic Approach to Uveitis
Uveitis · Intermediate Uveitis · Posterior Uveitis
Primary: Number of Participants With at Least 2-step Decrease in Vitreous Haze (VH) — 4; 4 participants
Phase 2 N=30 Autologous Cord Blood Stem Cells for Autism
Autism
Primary: Change in Language (Total Standard Score, Range 40 - 160) — 79.62; 79.66; 80.45; 80.59 units on a scale
N/A N=32 Transcranial Alternating Current Stimulation for Major Depressive Disorder
Major Depressive Disorder · MDD
Primary: Change in the Montgomery-Asberg Depression Rating Scale (MADRS) Score — -13.60; -8.82; -8.27 units on a scale — p=>0.10
N/A N=70 Evaluation of the Safety and Efficacy of an Oxalate Gel or Negative Control on Dentinal Hypersensitivity
Dentin Sensitivity
Primary: Change From Baseline Air Challenge — -1.200; -0.086 units on a scale