65,437 trials
Opioid Dependence
Primary: Percent of Weekly Urine Samples Negative for Opiates — 64.5; 81.3; 71.1; 66.7 percentage of negative urine samples — p=0.48
Healthy
Primary: AUC0-t — 38.3; 40.2; 43.6; 70.4 ng*h/mL
Asthma
Primary: Change in Mean SABA Use — -0.41; -0.31 mean puffs per day
HCMV Reactivation or HCMV End-Organ Disease
Primary: Number of Participants With "HCMV Prophylaxis Failure" — 16; 10; 10; 21 Participants — p=0.007
Healthy Controls
Primary: Glutamate + Glutamine (Glx) Response — 0.015; 0.007 Glx over creatinine ratio
Essential Hypertension
Primary: Mean Change of Diastolic Blood Pressure — -10.15; -7.19; -6.70 mmHg — p=<0.05
Idiopathic Pulmonary Fibrosis
Primary: Percentage of Patients With On-treatment Gastrointestinal (GI) AEs (SOC GI Disorders) From Baseline to Week 12 — 52.9; 69.8 percentage of participants
Coronary Artery Disease · Coronary Artery Stenosis · Coronary Disease
Primary: Number of Cardiac Death/TV-MI/ID-TLR (TLF) — 102; 41 Participants
Relationship, Marital · Marital Conflict
Primary: Relationship Satisfaction — 8.335; 8.37; 10.63; 9.555 units on a scale — p=<0.001
Alzheimer's Disease
Primary: Change From Baseline in Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) Total Score at Week 24 — -0.3; 0.8; 0.4; -0.5 Score on scale — p=0.159
Alzheimer's Disease
Primary: Cognitive Improvement Measured Using Montreal Cognitive Assessment (MoCA) — -0.667; 1.8 MOCA score change at 2 weeks
Nephrogenic Diabetes Insipidus
Primary: 24h Urine Volume — 6475; 4178; 6652; 4188 urine volume in mL/d
Migraine Disorders
Primary: Time to 10%, 50%, 90% and Complete Gastric Empting of the Radioactive Markers Representing Sumatriptan, Naproxen and Eletriptan — 0.100; 0.130; 1.195; 1.300 hours (hr)
Alcoholism · Alcohol Abuse · Smoking
Primary: Percentage of Heavy Drinking Days During the Last 8 Weeks of Treatment — 2.07; 2.25 log transformed percentage of days
Infections, Herpesviridae
Primary: Mean Percent Days of Subclinical Shedding as Determined by Type-specific Polymerase Chain Reaction (PCR) Assay for HSV-2 — 1.5; 5.1 Percentage of days — p=<0.001