N/A N=1,200 Patient Navigation for Lung Screening at MGH Community Health Centers
Lung Cancer
Primary: Chest CT Completion — 124; 138 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=96 Zostavax® at Minimum Release Specification Approaching Expiry (V211-044)
Herpes Zoster
Primary: Geometric Mean Titre (GMT) of Varicella Antibodies — 215.8; 674.0 gpELISA units/mL
N/A N=45 Assessment of Liver Cancer Response to TACE Using MultiHance-Enhanced MRI.
Hepatocellular Carcinoma
Primary: Nodule Size — 6.4 centimeters
Phase 2 N=18 Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
Adult Primary Hepatocellular Carcinoma · Advanced Adult Primary Liver Cancer · Localized Unresectable Adult Primary Liver Cancer
Primary: Dose-limiting Toxicities (DLT) and Maximum Tolerated Dose (MTD) of Belinostat in Patients With Inoperable HCC (Phase I) — 0; 0; 0; 1 Participants
Phase 3 N=945 Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067)
Unresectable or Metastatic Melanoma
Primary: Progression Free Survival (PFS) — 6.87; 11.50; 2.89 months — p=<0.0001
Phase 3 N=146 A Study to Evaluate the Efficacy and Safety of ABT-493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1, 2, 4, 5 or 6 Infection and Compensated Cirrhosis
Hepatitis C Virus Infection · Chronic Hepatitis C · Compensated Cirrhosis
Primary: Percentage of Participants With Sustained Virologic Response 12 Weeks Post-treatment (SVR12) — 99.3 percentage of participants
Phase 3 N=159 IVPCA in the Management of Pain Following Major Intracranial Surgery
Intracranial Surgery
Primary: Hourly Pain Scores — 2.5; 3.6; 3.7; 5.2 units on a scale
N/A N=76 Evaluation of a Computerized Opioid Overdose Prevention Program
Computer + Fluency · Computer Only · Treatment as Usual
Primary: Knowledge Gain — 30.6; 30.5; 27.56; 40.7 units on a scale
Phase 2 N=101 Dose-Escalation Study of TH-302 in Combination With Doxorubicin to Treat Patients With Advanced Soft Tissue Sarcoma
Soft Tissue Sarcoma
Primary: Maximum Tolerated Dose (MTD) Measured of TH-302 When Used in Combination With Doxorubicin and Prophylactic Growth Factor Support in Subjects With Advanced Soft Tissue…
Phase 2 N=25 Positron-Emission Tomography With Vesicular Monoamine Transporter Ligand ([18F]-DTBZ) In Healthy Elderly And Young Subjects
Healthy
Primary: Age-Dependent Change in Striatal 18F-DTBZ Uptake of Healthy Subjects. — 0.05 SUVR
Phase 2 N=57 Trial of Sertraline to Treat Children With Fragile X Syndrome
Fragile X Syndrome
Primary: Change in Mullen Scales of Early Learning - Expressive Language Raw Score — 19.3; 21.3; 21.3; 25.04 units on a scale
N/A N=449 Biological Basis of Individual Variation in Social Cooperation
Healthy
Primary: Healthy Volunteers-OT, Placebo: Mean Percent Signal Change in Right Caudate Nucleus in Men — 0.21; 0.07 percent signal change
Phase 3 N=190 Kansas University DHA Outcome Study (KUDOS) Follow-Up
Pregnancy
Primary: Weschler Preschool and Primary Scale of Intelligence, 3rd Edition; Full Scale IQ — 98.78; 98.75 units on a scale
Phase 2 N=30 Sodium Nitrite in Acute Myocardial Infarction
Acute Myocardial Infarction
Primary: Ischemia Area at Risk as Determined by Paired Single-photon Computed Tomography Studies With Technetium Tc99m Sestamibi.
N/A N=36 Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
Major Depressive Disorder
Primary: Change From Baseline in Montgomery Asberg Depression Rating Scale at 2 Weeks — 23.5; 23.8; 11.9; 21.9 units on a scale — p=<0.001