65,437 trials
Seizures · Epilepsies, Partial · Epilepsy, Complex Partial
Primary: Time to Next Seizure or Rescue Medication During the Double-blind Period (Kaplan-Meier 50th Percentile) — 5.92; NA Hours — p=0.012
Hydromorphone Use · Acute Postoperative Pain · Patient Satisfaction
Primary: Hydromorphone Use at 24 Hours — 4.56; 9.9 milligrams
HIV Infections
Primary: Number of Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Ribonucleic Acid (RNA) Viral Load <50 Copies/mL — 79; 78 participants
Depression
Primary: Adherence to Antidepressant Medication — 78.4; 61.9; 60.1; 40.2 percentage of adherence patients
Alzheimer's Disease
Primary: Change From Baseline in NPI-C Combined Agitation and Aggression Subscores (NPI-C A+A). — -4.3; -4.2 units on a scale
Smoking
Primary: Maximum Concentration (Cmax) of Nicotine Following Single Use of THS 2.2, CC and NNS — 9.62; 12.42; 10.52; 3.51 ng/mL
Class IV Angina
Primary: All Cause Mortality — 1 participants
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes
Myocardial Infarction
Primary: First Event of Cardiovascular Mortality, Re-hospitalization or Extended Initial Hospital Stay Due to Diagnosis of Heart Failure, Sustained Ventricular Tachycardia or…
Multiple Sclerosis
Primary: Walking Speed as Assessed by 25' Timed Walk — 22.7; 10.6; 23.9; 9.8 seconds
Pediatric Traumatic Brain Injury
Primary: Number of Participants Who Experienced Adverse Events — 0; 2 participants
Breast Cancer
Primary: Time to Progression (TTP) in Women With Hormone Responsive Advanced Breast Cancer Treated With Combination of Exemestane and Fulvestrant. — 6.9 months
Systemic Lupus Erythematosus
Primary: Percentage of Participants Achieving an Systemic Lupus Erythematosus (SLE) Responder Index [SRI (4)] Response With Oral Corticosteroids (OCS) Tapering at Day 169 — 17.6…
Epilepsy
Primary: Percent Reduction Over Placebo for Partial Onset Seizure (Type I) Frequency Over the Treatment Period Standardized to a 28-day Duration — 22.8; 23.2; 0 Percentage of…
Pulmonary Arterial Hypertension
Primary: Change in 6-minute Walk Distance — 13.5 m