Phase 4 N=16 PharmacofMRI of Anxiolytic Medications (Pregabalin)
Anxiety Disorders
Primary: Effect of Pregabalin (Two Doses) Versus Placebo — 0.6; -0.1; 0.6 % signal change L amygdala + anticipn
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=16 Remifentanil Intravenous Patient Controlled Analgesia (IVPCA) for Ablation of Idiopathic Ventricular Tachycardia
Tachycardia, Ventricular
Primary: Inhibition of Idiopathic Ventricular Tachycardia
Phase 4 N=38 Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
Hypertension
Primary: Pulse Wave Velocity (Measure of Arterial Stiffness) — 9.4; 8.9 meters per second (m/s)
Phase 4 N=88 Optimizing Body Composition for Function in Older Adults
Obesity · Overweight With Indications for Weight Loss
Primary: Appendicular Non-bone Lean Mass — -2.53; -2.49; -2.04; -1.45 kg
Phase 4 N=44 The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
High Blood Pressure
Primary: Endothelial Function Measured by Forearm Blood Flow (FBF) at 12 Weeks — 2.739; 2.679; 1.963; 2.221 mL/100 mL/min
Phase 4 N=256 Effects of Low Sodium Intake on the Anti-proteinuric Efficacy in Hypertensive Patient With Olmesartan
Hypertension · Chronic Kidney Disease · Microalbuminuria
Primary: ∆Albuminuria by 24-hour Urine Protein Excretion — 483.5; 569.9; 487.3; 417.4 mg/day — p=0.006
Phase 4 N=15 Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
Metabolic Syndrome
Primary: Ex Vivo Effects of Treatment With Vytorin Versus Zocor for 6 Weeks on Platelet Alpha Thrombin PAR-1 Receptor Expression — 35.4; 34.5; 23.6; 22.5 ng/dl
Phase 4 N=181 Everolimus in de Novo Heart Transplant Recipients
Cardiac Transplantation
Primary: Participants With at Least One Occurrence of Safety Composite Endpoint After 6 Months by Treatment Group — 40; 30 participants — p=0.1043
Phase 4 N=55 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue
Fibromyalgia, Primary
Primary: Brief Fatigue Inventory — 2.86; 4.29 units on a scale — p=<0.05
Phase 4 N=203 Study in Adolescents With Schizophrenia or Bipolar Disorder
Bipolar I Disorder · Schizophrenia
Primary: Mean Change From Baseline to 52 Weeks in Body Mass Index (BMI) for All Participants — 3.64; 2.83 kilograms per meter squared (kg/m^2) — p=0.150
Phase 4 N=200 Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
Mycoses · Fungemia · Central Nervous System Fungal Infections
Primary: Frequency of Fungal Infection — 5; 8 participants
Phase 4 N=152 A Study of the Effect of Ezetimibe on Glucose Metabolism in Type 2 Diabetics With Hypercholesterolemia (P06541)
Hypercholesterolemia
Primary: Change in Glycated Hemoglobin (HbA1c) From Baseline — 0.22; 0.14 Percent
Phase 4 N=60 TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management
Postoperative Pain
Primary: Postoperative Pain Score on Coughing at 6 hr — 5.28; 3.59 units on a scale
Phase 4 N=154 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds
Wrinkles
Primary: Efficacy — 77; 74; 73; 72 participantes rated improved and higher
Phase 4 N=29 Measuring Smoking Behaviors While Using Varenicline
Nicotine Dependence
Primary: Smoking Topography: Total Puff Volume — 523.4; 684.6 milliliters