65,437 trials
Schizophrenia
Primary: Percentage of Participants Without Relapse at Week 48 During the Double-Blind Phase — 91.5; 90.0 Percentage of Participants
Bacterial Infections · Virus Diseases
Primary: Geometric Mean Concentration of Antibodies to Polyribosylribitol Phosphate Antigen — 5.51; 6.10; 6.59; 3.76 µg/mL — p=<0.001
Leber Hereditary Optic Neuropathy
Primary: The Best Corrected Visual Acuity(BCVA) — 1.40; 1.69; 1.36; 1.58 logMAR
Renal Osteodystrophy
Primary: Percent Reduction in PTH — 27; 10 % change in PTH baseline to 3 months
Gastro-esophageal Reflux Disease
Primary: TRPV1, GDNF, and NGF mRNA Expression of Esophageal Mucosa — 1.14; 3.25; 2.33; 1.39 Fold change
Treatment Resistant Depression · Generalized Anxiety Disorder
Primary: Change From Baseline in Clinical Global Impressions Improvement (CGI-I) Scale at 3 Months — 545; 386 Participants
Healthy
Primary: Systolic Function: Global Longitudinal Left Ventricular (LV) Strain: 20 Minutes Pre-dose — -19.779; -20.483 percent change
Lymphocytic Leukemia, Chronic
Primary: Percentage of Participants With Death or Disease Progression — 24 percentage of participants
Myelofibrosis
Primary: The Primary Endpoint is Progression-free Survival. — 24; 11 participants
Smoking Cessation
Primary: Occurrence of Neuropsychiatric (NPS) Adverse Events (AE) - the Primary Study Endpoint — 1.3; 2.2; 2.5; 2.4 percentage of participants — p=0.0652
Psoriasis Vulgaris
Primary: Treatment Success According to the PGA — 38.3; 22.5 percentage of subjects — p=<0.001
Sleep Apnea Central · Cheyne-Stokes Respiration · Obstructive Sleep Apnea
Primary: Number of Breathing Events Identified by the Continuous Positive Airway Pressure (CPAP) Device Compared to a Simultaneous Polysomnography — 16.5; 18.1; 11.4; 11.5…
Endothelial Dysfunction · Hyperhomocysteinemia · Hypertension Grade I, Subgroup "Borderline" (WHO)
Primary: Change in Endothelial Function Between the Visit at Start of Supplementation Phase and the Visit on the Final Day of the 4 Week Supplementation Phase (Delta "lnRHI")…
Pain, Postoperative · Postoperative Nausea and Vomiting
Primary: Incidence of Rescue Analgesics Requirement — 47.9; 53.8 Percentage of Participants
Obesity · Endothelial Dysfunction · Vitamin D Deficiency
Primary: Flow Mediated Dilatation (FMD) — 9.5; 10.4 percentage increase in BAD — p=0.59