12,372 trials
Breast Cancer
Primary: Percentage of Participants With Total Pathologic Complete Response (tpCR) as Assessed by the Independent Review Committee (IRC) — 39.3; 21.8 percentage of participants…
Hereditary Angioedema (HAE)
Primary: Number of Participants With Treatment-emergent Adverse Events (TEAEs) — 7 Participants
Parkinson's Disease
Primary: Change From Baseline in Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II + Part III Total Score — 1.87; -4.52 Units on a scale…
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Adverse Events: Frequency and Severity — 272; 242; 275; 226 Participants
Migraine Headache
Primary: Change in Self-Assessed Pain — 51; 59 percentage change
Ankle Fractures · Pain, Postoperative · Local Infiltration
Primary: VAS — 2.81; 2.13; 3.52; 4.52 units on a scale (VAS)
Chronic Obstructive Pulmonary Disease, COPD · Low Peak Inspiratory Flow Rate (PIFR)
Primary: Change From Baseline in Trough FEV1 on Day 29 — 63.0; 47.3 mL
Chronic Idiopathic Constipation
Primary: Spontaneous Bowel Movement (SBM) Frequency at Week 1 — 3.1; 4.4 SBMs/week — p=0.007
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Change From Baseline in Trough FEV1 on Day 85 — 59.81; 126.85; -19.41 mL
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Change From Baseline in Trough FEV1 on Day 85 — 115.58; 102.90; -44.92 mL
Amyotrophic Lateral Sclerosis (ALS)
Primary: Change From Baseline in Revised ALS Functional Rating Scale (ALSFRS-R) Score in Full Analysis Set (FAS) Population at 24 Weeks — -5.01; -7.5 units on a scale
Malaria · HIV Infections
Primary: Incidence-density of Malaria Defined as the Number of Incident Episodes of Malaria Per Time at Risk. — 1.32; 2.25 Episodes/ Person-Yr at Risk — p=0.04
Chronic HCV Infection
Primary: Percentage of Participants With Sustained Virologic Response 12 Weeks After Discontinuation of Therapy (SVR12) — 100.0; 99.2 Percentage of participants — p=<0.001
Psoriasis
Primary: Pruritus Intensity Visual Analogue Scale Score at Week 32 — 8.8; 27.1 Units on a scale — p=0.0055
Depression
Primary: Depression Remission, as Measured by the Hamilton Rating Scale for Depression — 13; 5; 43; 12 number of remitted patients