Phase 3
Completed N=190
Magnetic Brain Stimulation for the Treatment of Adult Depression
Source: ClinicalTrials.gov NCT00149838 ↗Enrolled (actual)
190
Serious AEs
0.0%
Results posted
Dec 2018
Primary outcomePrimary: Depression Remission, as Measured by the Hamilton Rating Scale for Depression — 13; 5; 43; 12 number of remitted patients
◆ Published Evidence
Highly cited
1,069citations · ~67 / year
Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.
Summary
This study will evaluate the safety and effectiveness of magnetic brain stimulation for the treatment of major depression in depressed adults with moderate treatment resistance.
Linked Publications (2)
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Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial.
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The painfulness of active, but not sham, transcranial magnetic stimulation decreases rapidly over time: results from the double-blind phase of the OPT-TMS Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Depression Remission, as Measured by the Hamilton Rating Scale for Depression |
13; 5; 43; 12 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of major depression with a current episode
- Hamilton Rating Scale for Depression score higher than 20
- No response or intolerance to antidepressant medication in the current depressive episode
Exclusion Criteria
- Current use of antidepressants
- Diagnosis of psychosis or anxiety disorder
- Current substance abuse
- Seizures or history of head trauma
Data sourced from ClinicalTrials.gov (NCT00149838) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.