12,372 trials
Clostridium Difficile-associated Diarrhea (CDAD)
Primary: Percentage of Participants With Confirmed Clinical Response (CCR) at End of Treatment (EOT) +2 Days — 77.6; 70.5 percentage of participants
Atopic Dermatitis
Primary: The Number of Patients in Each Treatment Group That Have Clinical Success — 21; 27 Participants — p=0.3353
Diabetes · Diabetes Mellitus, Type 2
Primary: Change From Baseline in HbA1c (%) (Glycosylated Haemoglobin) — -1.48; -1.40 percentage of HbA1c — p=0.2430
Squamous Cell Carcinoma, Non-Small-Cell Lung
Primary: Kaplan-Meier Estimate of Progression-Free Survival (PFS) From Randomization Into Maintenance — 3.12; 2.60 months — p=0.3486
Infections, Streptococcal
Primary: Number of Subjects Reporting Rectal Temperature Above (>) 39.0 Degrees Celsius (°C) — 31; 6; 30; 13 Participants
Fever
Primary: Time Weighted Sum of Temperature Difference (WSTD) From 0 to 8 Hours — 9.28; 12.54; 11.09; 12.39 degrees fahrenheit — p=0.002
Hyperkalemia
Primary: Mean Serum Potassium Between Maintenance Phase Study Days 8 to 29, Inclusive (MP-ITT Population). — 5.0603; 4.7544; 4.5081; 4.3742 mmol/L
Meningoccocal Disease · Meningococcal Meningitis
Primary: Percentage of Subjects With Human Serum Bactericidal Activity Titers (hSBA) ≥ 4 or ≥ 5 Against Neisseria Meningitidis (N. Meningitidis) Serogroup B Strains — 51; 53; 61…
Diabetes Mellitus, Type 2 · Cardiovascular Diseases · Risk Factors
Primary: Major Adverse Cardiovascular Events (MACE) Composite of Cardiovascular (CV) Death, Non-Fatal Myocardial Infarction (MI), and Non-Fatal Stroke — 30.36; 28.41; 25.37…
Migraine, With or Without Aura
Primary: Change From Baseline in Mean Monthly Migraine Days (Migraine/Probable Migraine Headache Days) Across the 12-Week Treatment Period — -2.85; -4.00; -3.76; -3.55 migraine…
Dental Pain
Primary: SPID (Summed Pain Intensity Differences) — 31.56; 17.71; 23.18; 14.86 score on a scale
Hemophilia A
Primary: Annualized Number of Total Bleeds in On-demand Treatment Arm (Weeks 0 -36) and in Each Prophylaxis Arm (Weeks 10 - 36, Excluding Rescue Bleeds) - Part A, Main Trial…
Tuberculosis · HIV Infections
Primary: Incidence of First Diagnosis of Active Tuberculosis, Death Related to Tuberculosis, or Death From Unknown Cause — 0.6506; 0.6736 Events per 100 person-years
Migraine
Primary: Change From Baseline in the Monthly Average Number of Headache Days of At Least Moderate Severity During the 12-Week Period After the First Dose of Study Drug — -2.5…
Scalp Psoriasis
Primary: Proportion of Patients in Each Treatment Group Who Are Considered a Clinical Success — 49; 41 Participants — p=0.2961