Phase 4 N=63 Abuse Potential of HORIZANT With and Without Oxycodone in Healthy, Nondependent Recreational Opioid Users
Abuse Potential
Primary: Drug Liking Visual Analog Scale (VAS) — 56.4; 84.9; 59.6; 64.6 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=508 Research and Innovation to Stop E-cigarette/Vaping in Young Adults
Nicotine Dependence · E-Cig Use
Primary: 7-day Point Prevalence Vaping Abstinence — 55; 54; 61; 59 Participants — p=0.14
Phase 4 N=60 Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D
Type 2 Diabetes
Primary: Mean Change in HbA1C ≤ 7.5% — -0.5; 0 % glycated hemoglobin — p=0.009
Phase 4 N=120 Sugammadex To IMprove Bowel Function
Bowel Dysfunction · Postoperative Complications · Neuromuscular Blockade
Primary: Gastric Emptying — 1120; 1130 log(ng*ml-1)*min — p=0.58
Phase 4 N=21 Effects of Sandostatin LAR® in Acromegaly
Acromegaly
Primary: IGF-1 Level on Sandostatin LAR — 336; 186; 487 ng/mL — p=<0.05
Phase 4 N=30 Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon
Cystic Fibrosis · Chronic Pancreatitis
Primary: Mean Change in Total Symptom Score (TSS) From Day 1 (Baseline) to Days 8, 15, 29, and 85 — 0.0012; 0.0480; 0.1506; 0.0791 score on a scale
Phase 4 N=642 Assessing the Integration of Tobacco Cessation Treatment Into Lung Cancer Screening (LCS)
Smoking, Tobacco
Primary: Number of Participants With Self-reported Past 7-day Smoking Abstinence — 12; 10; 12; 15 Participants
Phase 4 N=727 Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP
Influenza
Primary: Microneutralization (MN) Assay Response to Cell-grown Influenza A/H3N2 - Seroconversion Rate (SCR) — 112; 48; 29 Participants
Phase 4 N=24 Steroid-reducing Effects of Crisaborole
Atopic Dermatitis · Eczema
Primary: Steroid Usage Quantity — 7.27; 10.78; 8.22 grams
Phase 4 N=307 Comparison of Misoprostol Ripening Efficacy With Dilapan
Labor Onset and Length Abnormalities · Induced; Birth
Primary: Number of Women Achieving Vaginal Delivery Within 36 Hours After Initiation of Cervical Ripening in ITT Population — 93; 90 Participants
Phase 4 N=114 Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly
Hip Fractures
Primary: Evaluation of the Analgesic Efficacy of Both Local Anesthetics in the Regional Block of Hip Fracture Surgery — 10; 4; 12; 14 Participants
Phase 4 N=160 Vitamin Deficiency in Immigrants, a Treatment Study
Vitamin D Deficiency
Primary: Serum-vitamin D — 19.7; 34.4; 38.7; 58.7 25(OH)D, nmol/L — p=0.001
Phase 4 N=14 Cannabidiol and CES1 Interactions in Healthy Subjects
Drug Interaction
Primary: Differences in the Geometric Mean Ratio (GMR) of the Peak Concentration (Cmax) Will be Compared Between the Two Exposure Conditions; i.e. Methylphenidate + CBD vs…
Phase 4 N=50 Envarsus on the Effect of Total Tacrolimus Dose/Trough Level Ratio on Renal Function (eGFR) in Kidney Transplantation
Renal Transplant Rejection · Kidney Transplant Failure and Rejection
Primary: Mean C/D Ratio — 1.68; 1.47; 1.86; 1.85 ng/mL*1/mg
Phase 4 N=20 Buffered Local Anesthetic
Dental Pain
Primary: Pain Score as Measured by the Behavior Pain Scale — 2.24; 2.61 score on a scale — p=0.005