Phase 4 N=6 Metabolism of 0.35mg Norethindrone vs 5mg Norethindrone Acetate
Contraception
Primary: Serum Concentration of Norethindrone — 15.69; 2.28; 13.56; 2.50 ng/ml
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=55 Total Joint Arthroplasty and Sleep
Primary Total Hip Arthroplasty · Primary Total Knee Arthroplasty
Primary: Epworth Sleepiness Scale (ESS) — 7.73; 7.81; 8.36; 7.31 score on a scale
Phase 4 N=14 Impact of Metformin and Polysorbate 80 on Drug Absorption and Disposition
Bile Salt Export Pump (BSEP) Transporter · Polysorbate 80
Primary: Area-Under-the-Curve (AUC) of Pravastatin After Metformin — 264.2; 170.5 ng/ml × h — p=0.02
Phase 4 N=23 Anesthesia and Postoperative Pain
Postoperative Pain
Primary: Score on a Pain Rating Scale (Numerical Analog Score) — 1.5; 4.9 scores on a scale
Phase 4 N=1,316 Improving Quitline Support Study
Tobacco Use Cessation
Primary: 7-Day Point-Prevalence Abstinence — 11; 7; 8; 10 Participants
Phase 4 N=641 Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
Gonorrhea · Chlamydia · Syphilis
Primary: Number of Quarterly Visits In Which an STI Was Detected — 61; 82; 36; 39 No. quarterly visits with STI event
Phase 4 N=89 Prazosin for Post-Concussive Headaches
Post-Traumatic Headache
Primary: Change From Baseline in Headache Frequency — 16.4; 18.5; -9.2; -7.4 headaches per month
Phase 4 N=109 The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
Asthma
Primary: Percentage of Participants Who Achieved Fractional Exhaled Nitric Oxide (FeNO) Less Than (<) 25 Parts Per Billion (Ppb) at Week 24 — 56.9; 10.8 percentage of…
Phase 4 N=449 Doxycycline PEP for Prevention of Sexually Transmitted Infections Among Kenyan Women Using HIV PrEP
HIV Infections · HIV/AIDS · Neisseria Gonorrheae Infection
Primary: Incidence of N. Gonorrhoeae, C. Trachomatis, or Early Syphilis Infection by Laboratory-based Diagnosis — 25.1; 29.0 Events per 100 person-years
Phase 4 N=20 Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
Kidney Transplant Rejection
Primary: Number of Participants With Biopsy-proven Acute Rejection — 1; 2 Participants
Phase 4 N=82 iPACK for Post-op Pain Following ACL Reconstruction
ACL Injury · Post Operative Pain
Primary: Pain Scores — 41.5; 29.8; 37.9; 47.4 units on a scale
Phase 4 N=27 IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIA
Rheumatoid Arthritis
Primary: IL-7 and IL-7R Expression in Peripheral Blood Mononuclear Cells of RA Patients With Active vs. Inactive Disease Treated With DMARD and/or CIMZIA. — 0.700; 1.330; 0.777…
Phase 4 N=60 Volume Versus Concentration: Clinical Effectiveness of Single Shot Quadrates Lumborum Block Using Either a High Volume/Low Concentration or Low Volume/High Concentration Injectate for Total Hip Arthroplasty.
Acute Pain
Primary: Consumption of Opioids During the First 24 Hours After Surgery. — 46.2; 35.0 mg morphine equivalents per 24 hours
Phase 4 N=34 A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis
Psoriasis
Primary: Percentage of Participants Who Achieve an Intertriginous PGA (iPGA) Score of Clear (0) or Almost Clear (1) With a ≥ 2-grade Improvement — 24 Participants
Phase 4 N=70 Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus
Type 1 Diabetes · Pregnancy, High Risk
Primary: Neonatal Hypoglycemia — 49.2; 50.1 mg/dL