Phase 4 N=70 Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
SRP · Minocycline HCl Microspheres · Biomarkers
Primary: Bacteria Load (log10) — -11.3; -10.9 log 10 copies/mL
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=100 Sugammadex Titration in Cardiac Surgery Patients
Coronary Artery Disease · Valvular Heart Disease · Aorta Disease
Primary: Total Dose of Sugammadex Required to Produce a Train-of-four Ratio of >0.9, Categorized as Greater Than or Less Than the Manufacturers Recommended Dose Based on the…
Phase 4 N=77 Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI
Coronary Artery Disease · Acute Coronary Syndrome
Primary: Platelet Reactivity Measured by VerifyNow — 23; 153; 65 PRU
Phase 4 N=22 EMERALD (Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders)
Lipid Disorder
Primary: Low-density Lipoprotein Cholesterol (LDL-C) Levels at Baseline and Day 30 — 110; 84.0 mg/dL
Phase 4 N=209 Dexamethasone for Migraine - Dose Comparison
Migraine
Primary: Number of Subjects With Headaches Who Have Sustained Headache Relief for 48 Hours — 35; 42 Participants
Phase 4 N=335 Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
Quality of Life · Injection Site Reaction · Adverse Drug Event
Primary: Total Number of Participants With Moderate or More Severe Fever, Chills, Myalgia, or Arthralgia in the Simultaneous Group and the Sequential Group Following Both…
Phase 4 N=494 Personalized Treatments for Depressive Symptoms in Patients With Advanced Heart Failure
Depression · Heart Failure
Primary: Depressive Symptom Severity as Measured by the Patient Health Questionnaire (PHQ-9) Depression Scale Results at 6 Months Follow up — 14.31; 14.54; 8.09; 7.53 score on a…
Phase 4 N=152 PENG Block Versus LP Block for THA Postop Pain
Pain, Postoperative · Hip Pain Chronic
Primary: Numeric Rating Scale (NRS) Pain Score — 4.0; 2.8 units on a scale
Phase 4 N=50 Safety of Argatroban Infusion in Conduction Disturbances
Stable Coronary Artery Disease (CAD) · Unstable Angina (Troponin Negative)
Primary: Mean Difference in QTc Interval Between ECG-2 and ECG-1 (ITT Population) — 0.94 milliseconds
Phase 4 N=64 Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children
Beta Thalassemia Major Anemia · Iron Overload
Primary: The Percentage of Patients in Each Treatment Group Who Still Have a Serum Ferritin Level < 1000 Micrograms Per Liter (μg/L) at Month 12 — 21; 12 Participants — p=0.0446
Phase 4 N=12 The Influence of Capsaicin Gel During Exercise Within the Heat
Acute Exercise · Heat Exposure
Primary: Skin Blood Flow — 188.4; 139.2 arbitrary units — p=0.284
Phase 4 N=5,204 A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men
Hypogonadism · Cardiovascular Diseases
Primary: Time From Randomization to the First Component Event of Major Adverse Cardiac Event (MACE): Number and Percentage of Participants With an Event — 182; 190 Participants
Phase 4 N=58 Comparison of Time to Extubation Using Sugammadex or Neostigmine
Neuromuscular Blockade · Chronic Obstructive Pulmonary Disease
Primary: Number of Minutes to Return of Baseline Muscle Tone — 3.9; 12.9 minutes
Phase 4 N=19 Endothelin-1 and Cardiac Allograft Vasculopathy (CAV)
Cardiac Allograft Vasculopathy
Primary: Macitentan: Nitroglycerin (NTG) Luminal Dilation Ratio as Proportion of Vasomotor Tone Attributable to Endothelin-1 (ET-1) — 0.33; 0.30 ratio
Phase 4 N=15 The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy Patients
Transthyretin Amyloid Polyneuropathy (ATTR-PN)
Primary: Change From Baseline in Neuropathy Impairment Score-lower Limb (NIS-LL) Total Score at Week 72 — 2.3 Units on a scale