17,261 trials
Dyspnea · Non-small Cell Lung Cancer · Small Cell Lung Cancer
Primary: Incidence of Grade 3 or Higher Hypotension, Acute Kidney Injury, Allergic Reaction, or Anaphylaxis, as Measured Using the National Cancer Institute Common Terminology…
Mantle Cell Lymphoma · Lymphoma, Mantle-Cell
Primary: Kaplan Meier Estimate for Progression Free Survival (PFS) by Independent Review Committee (IRC) Central Review — 37.6; 22.7 weeks — p=0.012
Acromegaly · Pituitary Gigantism
Primary: Total-group Response Rate at Month 3 — 18.2 Percentage of participants
Pulmonary Arterial Hypertension
Primary: Number of Subjects Reporting at Least One Treatment-Emergent Adverse Event (TEAE) — 27 Participants
Lymphoma, Large B-Cell, Diffuse
Primary: Percentage of Participants Who Achieved a Complete Response (CR) at the End of Induction Therapy — 54.1; 66.7 percentage of participants
Central Nervous System Neoplasm · Pineoblastoma · Recurrent Medulloblastoma
Primary: Overall Survival — 2.43; 13.6 percent probability
Inflammation
Primary: Changes in the Interleukin-6 Level Between Groups — 0; -0.1; -0.6; 3.8 pg/ml
Rhinitis
Primary: Mean Total Nasal Symptom Score (TNSS) and Its Individual Components on Day 8 — 6.53; 3.65; 6.57; 4.14 Score on scale
Primary Bile Acid Malabsorption · Secondary Bile Acid Malabsorption · Chronic Diarrhoea
Primary: Changes in Fasting FGF19 — 71; 25; 130 percentage increase of baseline — p=0.007
Nasopharyngeal Nonkeratinizing Carcinoma · Recurrent Nasopharynx Carcinoma · Stage III Nasopharyngeal Carcinoma AJCC v7
Primary: Confirmed Response Rate (Complete Response or Partial Response) Based on RECIST Version 1.1 — 20.5 percentage of patients with a response
Allergic Rhinitis · Allergic Rhinoconjunctivitis
Primary: Mean Total Symptom Score (TSS) After 10 Months of Treatment (Visit 6) Compared to Placebo — 10.01; 8.06; 8.19; 7.69 Score on a scale — p=0.057
Stroke · Cerebrovascular Accident (CVA) · Hemiparesis
Primary: Mean Percent Change From Baseline in Area Under the Curve for Objectively Measured Spastic Catch Response of the Wrist Flexors at Fast Speed — 13.678; -8.783; 15.927…
Hypoplastic Left Heart Syndrome · Hypoplastic Right-sided Heart Complex
Primary: Area Under the Curve for Ambrisentan Plasma Concentration — 7871.46 ng*hr/mL
Metastatic Colorectal Cancer
Primary: Number of Participants That Have Any Grade HFSR Toxicity — 7 Participants
Ovarian Cancer
Primary: Number of Participants With Overall Response — 1; 3 Participants