Phase 1 N=12 Study in Healthy Adults Evaluating PF-07202954
Non-Alcoholic Fatty Liver Disease · Liver Fibrosis
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs): Part 1 — 3; 0; 1; 2 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=283 Effectiveness and Safety of Combination of Nebivolol and Zofenopril in Hypertensive patIents Versus Each Monotherapy
Hypertension
Primary: Change in Mean Sitting DBP Between Week 0 (Visit 2) and Week 8 (Visit 3) — -9.3 mmHg — p=<0.001
N/A N=91 Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
Smoking · Tobacco Smoking · Tobacco Use
Primary: Concentration of 3-hydroxypropylmercapturic Acid (3-HPMA) — 786.07; 674.08; 781.63; 765.28 ng/mg creatinine
Early Phase 1 N=5 Nicotinamide Riboside in LVAD Recipients
Heart Failure，Congestive · Heart Failure New York Heart Association Class IV · Mitochondrial Alteration
Primary: Number of Participates Experiencing Treatment-Emergent Adverse Events (Safety and Tolerability) — 2 Participants
Phase 3 N=5,098 Seasonal Malaria Vaccination (RTS,S/AS01) and Seasonal Malaria Chemoprevention (SP/AQ) Extension Study
Malaria,Falciparum · Child, Only
Primary: Incidence of Clinical Episodes of Malaria — 338.1; 421.3; 178.9 Episodes per 1,000 child years at risk
N/A N=248 A Study to Learn About Recifercept in Patients With Achondroplasia
Achondroplasia
Primary: Mean Height Growth at Month 3 — 1.11; 0.84; 0.75; 1.07 Ratio
N/A N=61 Sleeping Healthy/Living Healthy Development
Sleep · Psychological Stress
Primary: Average Sleep Duration (Past 2 Weeks) — 404.2418126; 394.9457195 minutes
Phase 2 N=222 Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer
Breast Cancer
Primary: Progression-free Survival — 21.8; 12.8 months — p=0.003
Phase 1 N=32 A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer
Breast Cancer
Primary: Change in the Biomarker (PD-L1) Expression — 11; 12; 0; 0 Participants — p=1.0
N/A N=906 European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Protocol. Covid-19
Sars-Cov2 Antibodies in Children and Adolescents Living With HIV
Primary: Number of Participants With at Least One Positive SARS-CoV-2 Antibody Test. — 563 Participants
N/A N=9 Chest Compression and Sustained Inflation
Newborn Infants Having Asystole or Bradycardia at Birth
Primary: Time Needed to Achieve Return of Spontaneous Circulation — 31; 138 seconds — p=0.05
N/A N=44 Impact of Debridement Invasiveness on Attachment Gain After Antiinfective Periodontal Therapy
Periodontitis · Periodontal Attachment Loss · Periodontal; Lesion
Primary: Change in Clinical Attachment Loss — -1.08; -1.22 mm
N/A N=1,061 Long Term Special Drug Use Investigation of Mepolizumab
Asthma
Primary: Number of Participants Whose Data Entered on Electronic Data Capture (EDC) System — 1040 Participants
N/A N=392 Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
Neck Pain · Chronic Pain · Pain
Primary: Neck Disability Index — 20.3; 20.5; 18.3 units on a scale
N/A N=12 Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO18)
Hypoxia
Primary: Accuracy of Sensor Oxygen Saturation by Arms Calculation — 2.0 percentage of SpO2