6,678 trials
Diabetes Mellitus, Type 2
Primary: Change in Endogenous Glucose Production (EGP) After Acute Exposure to a Single Dose and Again After 16 Weeks of Treatment — -0.18; 0.14; -0.08; -0.03 mg/kg.min
Postpartum Depression
Primary: Percentage of Participants With At Least One Treatment-Emergent Adverse Event (TEAE) Leading to Dose Interruption/Discontinuation — 7.1 percentage of participants
HIV-1-infection · Hepatitis B
Primary: HIV-1 RNA at Week 24 — 25 Participants
RheumatoId Arthritis
Primary: Signs and Symptoms: Mean DAS28 Post Baseline — 3.26; 3.62; 3.06; 3.42 score on a scale — p=<0.0001
Cardiovascular Disease · Cardiomyopathy · Heart Disease
Primary: Change in Endothelial Progenitor Cells — -10.01; 5.19 Percentage of EPCs
Meningitis, Meningococcal
Primary: Number of Human Blood Samples Collected for Conversion Into Serum at Day -83 — 5578; 1936 Blood samples
Idiopathic Scoliosis
Primary: Unbound Cefazolin Concentration in Skeletal Muscle — 3.22; 5.84 µg/ml/kg
Acute Bleeding on Long-Term Anticoagulation Therapy · Hemorrhage · Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time)
Primary: Number of Participants Who Demonstrated Significant Reversal of INR Within 15 Minutes — 21; 33 Participants
Dermatitis Atopic
Primary: Change From Baseline in Intraepidermal Nerve Fiber Density on Lesional Skin at Week 17 — 8.4567; 4.2618 F/mm^2
Urea Cycle Disorder
Primary: Rate of Treatment Success (Percentage of Participants Defined as Treatment Success at Week 4) During the Initial Treatment Period — 81.8; 80.0 percentage of participants…
Intraoperative Bleeding
Primary: Surgical Field Grading Score — 3.54; 3.23 score on a scale — p=0.77
Plaque Psoriasis
Primary: Number of Subjects to Exhibit Adrenal Suppression as Measured by a Cosyntropin Stimulation Test — 6; 17 Participants
Hepatitis B, Chronic
Primary: Number of Participants With HBV DNA <20 IU Per mL — 257; 261; 257; 256 Participants
Healthy
Primary: Change in Baseline Visual Evoked Potential (P100) Amplitude
Thoracic Surgical Procedures
Primary: Total Opioid Consumption — 187.36; 164.70 mg morphine equivalent (MME)