12,372 trials
Binge-Eating Disorder · Obesity
Primary: Binge-Eating Frequency — 2.95; 2.33; 0.96 Binge-eating episodes (past 28 days)
Cervical Dysplasia · Cervical High Grade Squamous Intraepithelial Lesion · HSIL
Primary: Baseline Biomarker-positive Participants for ITT Population: Percentage of Participants With No Histologic Evidence of Cervical HSIL on Histology Sample and No Evidence…
Chronic Hand Eczema
Primary: Number of Participants With IGA-CHE TS at Week 16 — 91; 11 Participants — p=<0.001
Endometrial Neoplasms
Primary: Progression-free Survival (PFS) Based on Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as Assessed by Blinded Independent Central Review (BICR)…
Psoriatic Arthritis
Primary: Percentage of Participants With American College of Rheumatology 50 (ACR50) Response — 6.8; 43.4 percentage of participants — p=<0.001
Heart Failure
Primary: Number of Participants All-cause Mortality, Measured at 1 Year. — 0; 0; 0; 1 Participants — p=1.000
Dry Eye Syndrome
Primary: Change From Baseline to Day 30 in Ocular Surface Disease Index (OSDI) Score — -6.8 score on a scale
Alagille Syndrome (ALGS)
Primary: Change in Fasting Serum Bile Acid (sBA) Levels From Week 18 to Week 22 — 17.643 micromoles per liter (mcmol/L)
HIV · Cardiovascular Diseases
Primary: Incidence Rate of Major Adverse Cardiovascular Event (MACE) — 4.95; 7.77 events per 1000 person-years
Healthy Volunteers (Meningococcal Infection)
Primary: Groups 1a and 2a: Percentage of Participants With Vaccine Seroresponse Measured by Serum Bactericidal Assay Using Human Complement (hSBA) at Day 30 Post 12-Month…
Moderate Chronic Plaque Psoriasis · Severe Chronic Plaque Psoriasis
Primary: Primary Endpoints: Pharmacokinetics (PK) - AUC — 2127.57; 2357.61 h*ug/mL
Acute Respiratory Viral Infection
Primary: Time to Resolution of Acute Respiratory Viral Infection (ARVI) Symptoms (ARVI, Confirmed by Polymerase Chain Reaction (PCR)). — 3.3; 4.4 day — p=0.0003
Ankylosing Spondylitis
Primary: Percentage of Participants With Assessment of SpondyloArthritis International Society 40% Response Criteria (ASAS40) Response at Week 16 — 22.5; 44.8 percentage of…
Hip Fractures
Primary: Count of Participants With Acute Post-operative Transfusion of Packed Red Blood Cells. — 118; 111 Participants — p=0.966
Presbyopia
Primary: Overall Composite Driving Z Score Approximately 1 Hour After Study Intervention Instillation — 0.118; -0.121 Z-score — p=0.0006