Phase 2 N=11 Pembrolizumab in Patients With Locally Advanced or Metastatic Skin Cancer
Recurrent Skin Carcinoma · Skin Squamous Cell Carcinoma
Primary: Response Rate of Pembrolizumab — 72.73 percentage of participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=17 Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma
Glioblastoma · Glioblastoma With Primitive Neuronal Component · Gliosarcoma
Primary: Proportion of Progression Free Survival Participants (PFS) at Six Months — 0.786 Proportion of participants
N/A N=138 Me & My Wishes: An Efficacy Trial Using Videos
Health Communication
Primary: Number of Participants With a Documented Discussion of Goals of Care — 12; 10 Participants — p=.105
Phase 2 N=22 Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis
Mycoses · Candidiasis, Invasive · Candidemia
Primary: Safety and Tolerability, Assessed by Adverse Events, Clinical Laboratory Results, Physical Examination Findings, ECG Results, and Vital Sign Measurements — 1; 1; 0; 0…
N/A N=4,318 Scaling CRC Screening Through Outreach, Referral, and Engagement (SCORE)
Colorectal Cancer
Primary: Proportion of Subjects Who Completed Colorectal Cancer (CRC) Screening Within 6 Months (Trial - Age Group 50-75) — 598; 192 Participants
N/A N=16 MyPhonak App Junior Pediatric Usability and Benefit Investigation
Hearing Loss
Primary: dB SNR (Decibel Signal to Noise Ratio) Score Using the OLSA (Oldenburg Sentence Test) Speech in Noise Test — -1.33; -2.83; 0.08 dB — p=<0.001
Phase 2 N=130 Efficacy and Safety of Aldoxorubicin Compared to Topotecan in Subjects With Metastatic Small Cell Lung Cancer
Metastatic Small Cell Lung Cancer
Primary: Progression-Free Survival (PFS) — 1.5; 2.7 Months
N/A N=208 Research on Expecting Moms and Sleep Therapy
Insomnia
Primary: Change in Insomnia Severity Index Scale Score — -6.054945; -2.212766 units on a scale
N/A N=69 Performance Evaluation of Daily Disposable Contact Lenses in Habitual Lens Wearers Who Use Digital Devices Frequently
Myopia
Primary: Lens Handling on Removal — 90; 95 Units on a scale
Phase 1 N=12 Pilot Trial of Ustekinumab for Primary Sjögren's Syndrome
Primary Sjögren Syndrome
Primary: Change in The European League Against Rheumatism (EULAR) Sjogren's Syndrome Patient Reported Index (ESSPRI) Score From Baseline to Week 24 — -0.125 score on a scale
Phase 2 N=318 Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee
Osteoarthritis, Knee
Primary: Difference in Change From Baseline Between EP-104IAR and Vehicle in WOMAC Pain Subscale — -2.89; -2.23 score on a scale — p=0.004
N/A N=250 Ancillary Study of Methylation Biomarkers in a Randomized Controlled Trial of a Personalized Prevention of Colorectal Cancer
Colorectal Cancer
Primary: Changes of Cytosine Modification in TMPRSS2 (5-mC at cg16371860) by Magnesium Treatment Versus Placebo — 0.007; -0.001; 0.012; -0.002 units on CpG sites — p=<0.05
N/A N=100 An Evaluation of the Utility of the ExSpiron Respiratory Variation Monitor During Upper GI Endoscopy
Biliary Tract Diseases · Stomach Neoplasms · Carcinoma, Pancreatic Ductal
Primary: Average Minute Ventilation in Patients Cared for Using the ExSpiron Respiratory Variation Monitor (RVM) Compared to Patients With Routine Monitoring in Patients…
N/A N=35 Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
Major Depressive Disorder · Anhedonia
Primary: Change in the Percentage of Trials That the Participant Chooses to Perform the Hard Task — -0.30; -0.22; -0.09 percentage of trials — p=0.049
Phase 2 N=17 Phase 2 Study of Telomelysin (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma
Esophagogastric Adenocarcinoma
Primary: Overall Response Rate, as Assessed by Radiographic Imaging — 3 Participants