65,437 trials
Surgery · Shoulder Impingement
Primary: Pupillary Pain Index (PPI ) — 1.8; 6.6 score on a scale
LGBTQ · Sexual Behavior
Primary: Change in Distress — 1.43; 1.57; 1.22; 1.34 score on a scale
Familial Cold Autoinflammatory Syndrome
Primary: Ratio of Fold Change From Pre-challenge to the Highest Post-challenge Value of White Cell Count (WCC) Between Treatment and Screening Period — 0.82 ratio of fold change
Breast Cancer Female
Primary: Participation Satisfaction in Social Roles and Activities: PROMIS — 45.75; 46; 48.09; 47.61 T-score — p=.54
Coronary Angiography · Coronary Angioplasty
Primary: Quick Disabilities of the Arm Shoulder and Hand (DASH) Questionnaire Score (0-100) — 0; 0 DASH Score change from baseline
Healthy
Primary: Setmelanotide Concentration-related Placebo-corrected Change From Baseline (CHFB) in Fridericia's Correction (QTcF) at Day 10 — 1.9; -1.5; -3.6; -3.5 milliseconds (msec)
Knee Pain · Chronic Osteoarthritis · Avascular Necrosis of the Femoral Condyle
Primary: Clinical Performance — .540; .442; .740; .763 score on a scale
Acute Radiation Syndrome
Primary: Adverse Events Related to BIO 300 Oral Powder — 0; 0; 0; 0 Number of Adverse Events
Hypertension
Primary: Number of Participants Who Measured Blood Pressure as Instructed (Assessed on Questionnaire) — 34; 47; 50 Participants — p==0.05
Contraceptive Usage
Primary: Feasibility of Application — 4.47; 4.52; 4.16; 4.26 units on a scale
Obesity · Heart Failure
Primary: Average Myocardial Blood Flow — 0.73; 0.97 mL/g/minute — p=<0.005
Stress
Primary: Heart Rate Measurement — 83.45; 82.80; 81.88; 84.38 beats per minute
Solid Tumors
Primary: Dose-escalation: Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious TEAEs — 3; 3; 4; 3 Participants
Non-Small Cell Lung Cancer · Epigenetic Therapy
Primary: Objective Response — 4; 1; 5; 3 Participants
Oncology · Acute Myeloid Leukemia
Primary: Maximum Tolerated Dose (MTD) — 0; 0; 0; 0 DLTs