65,437 trials
Non-small Cell Lung Cancer
Primary: Phase 1b: Frequency of Treatment Emergent Adverse Events (TEAEs) as Assessed by CTCAE v4.03. — 47; 66; 2; 4 Participants
Restless Legs Syndrome · Neuropathic Pain
Primary: Percent Change MSNA Burst Frequency From Baseline to 60 Minutes — -29; -24 Percent change MSNA burst frequency
Hypothalamic Obesity
Primary: Percentage of Participants With ≥ 5% Reduction in BMI From Baseline After 16 Weeks of Setmelanotide Treatment — 88.9 percentage of participants — p=<0.0001
Invasive Mucormycosis · Invasive Aspergillosis
Primary: Number of Participants With Treatment Emergent Adverse Events (TEAEs) — 29 Participants
Covid19
Primary: The Number of Participants With Treatment Emergent Adverse Events of Ampion Compared to Placebo — 5; 9; 3; 5 Participants
Chronic Kidney Disease Mineral and Bone Disorder · Renal Osteodystrophy · Vascular Calcification
Primary: Percent Change in PTH Levels — 0; -54.14; -64.04 percentage of change in PTH levels
Tibial Fractures · Intra-Articular Fractures · Fracture Fixation, Internal
Primary: Resorption of Study Device — 4 Participants
Mild Tricuspid Regurgitation · Moderate Tricuspid Regurgitation · Tricuspid Regurgitation
Primary: Percentage of Participants With Treatment Failure — 10.2; 3.9 percentage of participants
Hepatocellular Carcinoma · Chemoembolization, Therapeutic
Primary: Percentage of Patients Correctly Identified as Requiring Tumor Re-treatment Two Weeks After Initial Chemoembolization — 94 percentage
Pro-opiomelanocortin (POMC) Deficiency Obesity
Primary: Percentage of Participants Who Reached ≥10% Weight Loss Threshold After 1 Year (Pivotal Cohort) — 80.0 percentage of participants — p=<0.0001
Erectile Dysfunction
Primary: Change From Baseline in the Erectile Function (EF) Domain of the International Index of Erectile Function (IIEF) Questionnaire, in Patients Randomised to MED3000, at…
Thrombotic Microangiopathies · Atypical Hemolytic Uremic Syndrome · Multiple Organ Dysfunction Syndrome
Primary: Survival — 15 Participants — p=<0.0001
Peristomal Skin Complication
Primary: Max Itching Within a Week at Steady State — 2.5; 2.4 score on a scale — p=0.625
Cardiac Arrest
Primary: Intention to Give CPR Instructions — 4.3 score on a scale
Breast Cancer · Lymph Node Mapping · Sentinel Lymph Node Biopsy
Primary: Proportion of Lymph Nodes Identified by IC2000/SPY-PHI Compared to the Proportion of Lymph Nodes Identified by Tc99m/Gamma Probe — 360; 266 Lymph Nodes — p=<0.0001