Phase 2 N=164 Bonipar for Acute and Chronic Musculoskeletal Pain
Chronic Pain · Musculoskeletal Pain
Primary: Change in Pain as Measured by Subjective Pain Intensity Rating (SPIR) — -2.3; -2.6 score on a scale — p=0.46
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=60 A Safety Study of Retinal Gene Therapy for Choroideremia With Administration of BIIB111
Choroideremia
Primary: Mean Best-Corrected Visual Acuity (BCVA) as Measured by the Early Treatment of Diabetic Retinopathy Study (ETDRS) Chart in Letters at Month 12 — 68.0; 76.5; 82.3; 81.2…
N/A N=63 Effect of Mental Imagery Training on Brain Plasticity and Motor Function in Individuals With Parkinson's Disease
Parkinson Disease
Primary: Change in Right Insula-dorsomedial Frontal Cortex Functional Connectivity Strength. — 93.2; 97.8 percent change from baseline — p=0.981
N/A N=34 Nuts and Oil Pilot Study
Metabolic Syndrome
Primary: Proportion of Participants With MetS With Epigenetic Age Acceleration — 0.21; 0.53 proportion of participants AgeAccelGrim>
Phase 4 N=32 Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery
Anterior Cervical Discectomy and Fusion (ACDF)
Primary: Incidence of Unacceptable Movement Under General Anesthesia — 1; 1 Participants
N/A N=17 Clinical Evaluation of the Efficacy of Fractional Radiofrequency for the Treatment and Reduction of Stretch Marks
Stretch Mark
Primary: Percent Change in Volume of Striae Via Antera 3D Imaging System Analysis From Baseline to 16 Weeks Post-final Treatment — -28.3 percentage change from baseline
Phase 3 N=332 Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
Chronic Rhinosinusitis
Primary: Change From Baseline in Symptoms as Measured by a Composite Score for Each Symptom of Nasal Congestion, Facial Pain or Pressure Sensation, and Nasal Discharge (Anterior…
Phase 3 N=118 A Sub-study of Cabotegravir (CAB) and Rilpivirine (RPV) in Human Immunodeficiency Viruses (HIV)-Infected Participants
Human Immunodeficiency Virus Type 1 (HIV-1)
Primary: Concentration at End of Dosing Interval (Ctau) of CAB LA Following Administration of CAB LA + RPV LA Q8W — 1.67; 1.61; 1.81 Micrograms per milliliter
Phase 2 N=16 StAT-TB (Statin Adjunctive Therapy for TB): A Phase 2b Dose-finding Study of Pravastatin in Adults With Tuberculosis
Tuberculosis · Pulmonary Tuberculosis
Primary: Frequency of Grade 3 or Higher Adverse Events — 8; 4 AEs Grade 3 or Higher
Phase 1 N=145 A Study to Compare the Pharmacokinetics of Two Different Tablets of Sotorasib in Healthy Participants
Healthy Participants
Primary: Maximum Observed Plasma Concentration (Cmax) of Sotorasib for Treatments A and B — 6650; 6540 ng/mL
N/A N=20 Treatment Resistant Depression (Pilot)
Depressive Disorder, Treatment-Resistant
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -9.0; -6.4 Scores on a scale — p=0.53
Phase 2 N=21 Pharmacokinetic Study With an Oral Suspension of Perampanel as Adjunctive Therapy in Pediatric Subjects With Epilepsy
Epilepsy
Primary: Dose Normalized Area Under the Concentration-Time Curve for Dosing Interval at Steady State (AUCtau,ss) of Perampanel During the Maintenance Period of the Core Phase for…
N/A N=59 Improving Parent-Child Interactions to Enhance Child Health
Child Obesity
Primary: Change in Child Body Mass Index (BMI) Percentile — 3.66; 1.74; 1.12; 0.88 percentile — p=.73
N/A N=9 rTMS and Botulinum Toxin in Primary Cervical Dystonia
Primary Cervical Dystonia · Dystonia
Primary: Dystonia Severity as Assessed by the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) — 13; 17 scores on a scale
Phase 1 N=16 Potential Influence of Esomeprazole on the Pharmacokinetics of Pritelivir
HSV Infection
Primary: PK - Cmax — 1102; 282 ng/mL