30 closest matches · ranked by relevance
Cancer
Primary: Number of Patients With ALT (Alanine Transaminase) >=3x (Times) Upper Limit of Normal (ULN) — 11 participants
Drug Toxicity · Healthy
Primary: The Proportion of Subjects Treated With Long-term Acetaminophen (4 g/Day) That Develops Persistent ALT Elevations. — 204; 47; 1; 0 participants
Alcohol Consumption
Primary: Change in Bile Salt Metabolism (C4 )Levels to Determine Effect of FXR
Healthy Volunteers · Hepatic Insufficiency · Diabetes Mellitus, Type 2
Primary: Pharmacokinetics: Area Under the Concentration Time Curve From Zero to Infinity (AUC[0-∞]) of LY2605541 — 85200; 67200; 64300; 66600 picomole*hours/liter (pmol*h/L)
Chronic Hepatitis · Chronic Hepatitis C · Chronic Alcoholic Hepatitis
Primary: The Change in Serum Alanine Aminotransferase Level From Baseline to 12 Weeks — 77.5; 105.5 IU/L
Liver Diseases
Primary: Aspartate Transaminase (AST) Change — -6.32 U/L — p=0.03
Healthy · Hepatic Insufficiency
Primary: Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Time Zero to Infinity (AUC [0-∞]) of LY3502970 — 130; 132; 209; 611 nanogram *hour per…
Diabetic Kidney Disease
Primary: Pharmacokinetic (PK) Parameter: AUCinf of Selonsertib and Its Metabolite GS-607509 — 3316.1; 3266.7; 2962.1; 2835.3 hr*ng/mL
Nonalcoholic Steatohepatitis · Non-alcoholic Fatty Liver Disease
Primary: Change in Alanine Aminotransferase (ALT) — -37.8; -14.9 U/L — p=0.0195
Non-Alcoholic Fatty Liver Disease · Non-Alcoholic Steatohepatitis
Primary: Correlation of the Liver Fat Percentage Reported From MRI-PDFF With Measurements Hepatorenal Index (HRI) of Ultrasound Biomarkers for Liver Fat. — 1.6 Hepatorenal Index
Urea Cycle Disorder
Primary: Liver Stiffness as Measured by Shear Wave Elastography — 13; 14 Participants
Mild Hepatic Injury
Primary: Changes in ALT(Alanine Transaminase) — 61.08; 55.68; 44.92; 53.82 IU/L
Hepatic Impairment · Healthy
Primary: Pharmacokinetic (PK) Parameter: AUCtau of Bulevirtide (BLV) — 152; 150; 215; 113 h*ng/mL
Fatty Liver
Primary: Hepatic Fatty Acid Oxidation
Non-alcoholic Fatty Liver Disease
Primary: Hepatic Insulin Sensitivity Index (HISI) — 0.8; 1.4 [10000/(μmol/min)x(mU/L)] — p=<0.019
Hepatic Impairment · Healthy Volunteers
Primary: Maximum Plasma Concentration (Cmax) of PF-07081532 — 2236; 2121; 2230; 1536 nanogram per milliliter (ng/mL)
Nonalcoholic Fatty Liver Disease (NAFLD)
Primary: Change in Intrahepatic Lipid Content Between Baseline and 6 Months as Measured by 1H-magnetic Resonance Spectroscopy (1H-MRS). Endpoints Were Assessed at Baseline and 6…
Liver Diseases · Hepatic Impairment
Primary: Plasma Maximum Concentration (Cmax) of Sisunatovir Following Administration of a Single Oral Dose — 81.25; 68.52; 73.85; 127.8 Nanograms/milliliter (ng/mL)
Adrenal Insufficiency · Cirrhosis · Spur Cell Anemia
Primary: Number of Participants With Cholesterol Esterification Deficiency — 10; 11 Participants
Depressive Disorder, Major
Primary: Pharmacokinetics: Area Under the Concentration Curve (AUC) — 601; 742; 961; 1020 hours times nanograms/milliliter
Type 2 Diabetes · Obesity
Primary: Insulin Sensitivity — 8 m value — p=<0.05
Non-alcoholic Fatty Liver Disease · Nonalcoholic Steatohepatitis
Primary: Median Total Specimen Length — 8; 14; 8; 11.5 mm
Non-alcoholic Fatty Liver Disease
Primary: Hematic Levels of Hepatic Enzymes AST — 35.4; 37.5; 31.6; 31.2 IU/L — p=<0.05
Nonalcoholic Fatty Liver · Nonalcoholic Steatohepatitis · Fatty Liver
Primary: Mean Difference in Aspartate Transaminase (AST) Value in U/L Unit Between Pre-imaging and day7 Post-imaging — -0.5 international units per liter
Nonalcoholic Fatty Liver · Nonalcoholic Steatohepatitis
Primary: Absolute Change in Intrahepatic Lipid Content, by 1H-MRS — -6.6; 3.6 Mean absolute percentage change
Non-Alcoholic Fatty Liver Disease · Obesity
Primary: Difference in the Distribution of Fecal Microbiota in Each Participant
Fatty Liver, Nonalcoholic · Diabetes Mellitus, Type 2
Primary: Action on Suspected Advanced Liver Fibrosis — 55; 4 Participants
Cystic Fibrosis · Liver Fibrosis
Primary: Elastographic Value in kPa Measured by Fibroscan — 4.7 kPa
Pulmonary Hypertension
Primary: The Incidence of Confirmed Serum Alanine Aminotransferase (ALT) or Aspartate Aminotransferase (AST) Concentrations > 3 x the Upper Limit of Normal (ULN) Considered to be…
Non-alcoholic Fatty Liver Disease
Primary: Change in ALT Index — 42.238; 33.524; 36.667; 36.238 U/L