Clinical Trial Search

Primary: Number of Participants With the Presence of Drug in the Tumor Tissue — 2 Participants

Primary: Progression-free Survival at 6 Months — 23 Percentage of participants

Primary: Response, Defined as Stable Disease or Objective (Partial or Complete) Response. — 0; 0; 0; 0 Participants

Primary: Progression-Free Survival — 7.71 weeks

Primary: Progression-free Survival (PFS) — 91.3 percentage of participants

Primary: Number of Participants With Objective Response — 4; 5; 12; 10 Participants

Primary: Number of Participants With Objective Response — 1; 1; 5; 19 Participants

Primary: 6-month Progression-free Survival (PFS), Defined as a Patient Being Alive and Progression-free 183 Days After the Date of Registration. — 33.35; 33.3; 25 percentage of…

Primary: Area Under the Receiver Operating Curve (ROC AUC) Values for PET Imaging Techniques — 0.98; 0.91; 0.89; 0.82 Probability

Primary: Percentage of Participants With an Objective Response and Long-term Stable Disease — 0; 11.1; 10.5; 0 percentage of participants

Primary: Invest Relation Btw Voxel-based Determ of Prolif Rate & Obser MR Imaging Featu (i.e., Ktrans or Microvas Permeabil; fBV, Tiss Fract Blood Vol), as Well With Spatially…

Primary: Overall Survival — 19 months

Primary: Endocrine Dysfunction — 14.5; 20.2 percentage of participants

Primary: Percent of Participants With Locoregional Control of Treating Brain Metastasis Patients — 92; 98.6; 46; 46 percentage of participants

Primary: Change in AUC0-18 of the Temozolomide Concentration (AUC-T) in Brain Interstitium Before and After Regadenoson Infusion — 19.1; 18.0 percentage of AUC

Primary: Number of Participants With Objective Response — 2; 1; 2; 27 Participants

Primary: Tumor to Background Ratios (TBR) Post-imaging for All Lesions With PET Uptake — 8.25; 8.75 Ratio of PET SUV

Primary: Number of Participants With Objective Response — 5; 4; 8; 14 Participants

Primary: Percentage of the Gross Tumor Volume With a BTB Opening of Ktrans > 0.005 Min-1 — 78.6; 85.6; 6.4; 74.4 percentage of gross tumor volume

Primary: [18F] Fluorothymidine ([18F]-FLT) Uptake as a Marker of Cellular Proliferation — 1.57; 3.00 SUV max — p=< 0.001

Primary: Number of Participants With Objective Response — 2; 2; 4; 19 Participants

Primary: Extent of Tumor Resection — 40; 7; 7; 4 participants

Primary: Percentage of Participants With Progression Free Survival at 6 Months. — 20.9; 29 Percentage of participants

Primary: Increase of Interferon Gamma Levels — 0 Participants

Primary: Median Progression Free Survival. — 10.5 months

Primary: Response Rate

Primary: Percentage of Participants With an Objective Response (Complete Response or Partial Response) — 4; 0 Percent of Participants

Primary: Proportion of Progression Free Survival Participants (PFS) at Six Months — 0.786 Proportion of participants

Primary: Percentage of Patients With ≥50% Seizure Reduction During the Maintenance Period Compared With Seizure Frequency Before Initiation of Perampanel

Primary: 1-year Event Free Survival (EFS) — 12; 24 percentage of participants — p=< 0.05