Phase 4 N=25 Treating Hearing Loss to Improve Mood and Cognition in Older Adults
Hearing Loss · Depression
Primary: Hamilton Rating Score for Depression (HRSD) — 12.04; 13.86 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=34 Longitudinal Outcomes of Hearing Aids
Presbycusis
Primary: Hearing Aid Benefit as Measured by the Glasgow Hearing Aid Benefit Profile (GHABP) — 3.68; 3.55; 3.63 score on a scale
N/A N=38 Age-related Hearing Loss and Lexical Disorders
Alzheimer Disease · Presbycusis · Lexical Syntactic Disorder
Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale
Phase 2 N=78 Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing Loss
Age-Related Hearing Loss
Primary: Change in Hearing Loss After 4 Weeks of Treatment — -1.114; -1.914 decibels (dB)
N/A N=151 Baltimore HEARS: Hearing Health Equity Through Accessible Research & Solutions
Age-related Hearing Impairment 1 · Personal Communication
Primary: Change From Baseline in Hearing Handicap Inventory for the Elderly (HHIE-S) — -13.2; .06 score on a scale
N/A N=276 Evaluation of Unilateral vs Bilateral Hearing Aids for the Treatment of Age-related Hearing Loss
Hearing Loss
Primary: Change in Hearing Aid Benefit as Measured by Abbreviated Profile of Hearing Aid Benefit (APHAB) — -19.74; -14.41 score on a scale — p=0.003
N/A N=977 Aging and Cognitive Health Evaluation in Elders (ACHIEVE)
Aging · Cognitive Decline
Primary: Change in Global Cognitive Function — -0.202; -0.200 score on a scale — p=0.96
N/A N=129 Hearing Loss Prevention for Veterans
Hearing Loss, Noise-Induced
Primary: Percentage of Time Spent at Sound Levels >80 Decibels — 4.4; 5.0; 6.3 percentage of time — p=0.289
N/A N=290 Impact of Hearing Aid Service-delivery Model and Technology on Patient Outcomes
Presbycusis
Primary: Hearing Aid Use Measured Using In-situ Glasgow Hearing Aid Benefit Profile (EMA-GHABP-Use) — 4.4; 4.1; 3.8; 4.5 score on a scale
Phase 2 N=72 Micronutrients to Prevent Noise-induced Hearing Loss
Noise-Induced Hearing Loss
Primary: Average Threshold Shift at 4 kHz in Both Ears — 3.94; 3.4; 2.77; 2.03 decibels — p=0.58
N/A N=19 Hearing Aid Quality and Reliability Study
Hearing Loss
Primary: Electroacoustic Evaluation of Hearing Aids in Accordance With Manufacturer Specifications, Day 1 — 38; 0 hearing aid devices
N/A N=49 Variability In Hearing Aid Outcomes In Older Adults
Hearing Loss · Presbycusis
Primary: Speech Intelligibility Score — 69; 78 percentage of correct responses
N/A N=17 Hearing Aid and Individuals With Cognitive Disorders
Presbycusis, Bilateral · Alzheimer Disease 2 Due to Apoe4 Isoform · Mild Cognitive Impairment
Primary: Hearing Aid Benefit as Measured by the International Outcomes Inventory for Hearing Aids (IOI-HA) — 3.9; 3.4; 3.7 score on a scale
N/A N=325 Hearing for Communication and Resident Engagement
Hearing Loss, Age-Related
Primary: Satisfaction With Social Participation — 49.7; 52.8; 51.2; 49.4 T-score — p=0.58
N/A N=18 PC-Based Rehabilitation of Auditory Function
Hearing Loss, Sensorineural
Primary: .Speech Discrimination Ability — 9.43; 0.46 signal to noise ratio in dB SNR
N/A N=18 Noise Reduction Preferences in Teenagers and Pre-teens
Hearing Loss
Primary: Subjective Rating of Listening Effort Questionnaire — 44.73; 44.5; 41.53; 35.86 units on a scale — p=0.007
Phase 1 N=30 Auditory Training and Hearing Aid Satisfaction
Hearing Impairment, Sensorineural
Primary: Change in Hearing Aid Satisfaction After Auditory Training — 1.9; 1.7 units on a scale — p==0.269
N/A N=40 Cochlear Implantation in Adults With Asymmetric Hearing Loss Clinical Trial
Hearing Loss
Primary: Change in Poor Ear Alone CNC Monosyllabic Word Understanding in Quiet — 0.09; 0.53; 0.44 percentage of words correct — p=<0.001
N/A N=37 Administration Method of Cognitive Screening in Older Individuals With Hearing Loss
Hearing Loss, Sensorineural · Cognitive Impairment
Primary: Cognitive Screening Results (Montreal Cognitive Assessment) — 28.69; 22.37; 23.375; 23 score on a scale
N/A N=10 Assessment of e-Audiology for Providing Clinical Services and Support
Hearing Loss, Age-Related · Presbycusis, Bilateral · Hearing Disability
Primary: Change From Baseline on the Hearing Handicap Inventory for the Elderly Screening Version (HHIE-S) — 3.2 scores on a scale
N/A N=24 Benefits of the HiResolution Bionic Ear System in Adults With Asymmetric Hearing Loss
Hearing Loss · Ear Diseases · Hearing Disorders
Primary: Change in Consonant Nucleus-Consonant (CNC) Word Recognition Test (Implanted Ear Only) — 2.13; 61.14 percentage of recognized words
Phase 2 N=23 FX-322 in Sensorineural Hearing Loss
Sensorineural Hearing Loss
Primary: Number of Participants With Treatment-emergent Adverse Event(s) (TEAEs) — 2; 3; 5; 6 Participants
N/A N=107 Sensory Integration of Auditory and Visual Cues in Diverse Contexts
Vestibular Disorder · Hearing Loss, Sensorineural
Primary: Root Mean Square Velocity Anterior-posterior [AP] in cm/s (RMSV) — 3.59; 3.30; 3.07 cm/s — p=0.005
N/A N=27 Audiobooks for Hearing Loss App as Auditory Training
Hearing Loss · Hearing Impaired Children · Hearing Impairment
Primary: Audiobooks Efficacy: Change in Slope of Curve for SNR Loss Scores on a Scale/Week for Partial BKB-SIN Hearing Test — 5.978; 5.889; 5.757; 5.600 units on a scale/week…
N/A N=106 Promoting Early Diagnosis of Congenital Hearing Loss With Patient Navigators
Congenital Hearing Loss
Primary: Number of Participants Who do Not Receive Diagnostic Audiological Testing (Aim 1) — 15; 8 Participants
Phase 2 N=95 FX-322 in Adults With Stable Sensorineural Hearing Loss
Sensorineural Hearing Loss · Noise Induced Hearing Loss · Sudden Sensorineural Hearing Loss
Primary: Word Recognition in Quiet — 23.8; 16.7; 15.8; 18.8 Percent — p=0.068
Phase 2 N=142 FX-322 in Adults With Acquired Sensorineural Hearing Loss
Hearing Loss, Sensorineural · Noise Induced Hearing Loss · Sudden Hearing Loss
Primary: Word Recognition in Quiet — 14.7; 11.1 Percent of subjects — p=0.525
N/A N=118 Smartphone Enabled Hearing Study
Hearing
Primary: International Outcome Inventory for Hearing Aids (IOI-HA) Survey Results — 25.5; 26.6 score on a scale
N/A N=65 Feasibility and Acceptability of Using Low-Gain Hearing Aids for Bothersome Tinnitus
Tinnitus · Hearing Aids · Normal Hearing
Primary: Tinnitus Functional Index Change — 53.31; 44.10; 64.93 units on a scale
N/A N=68 Clinical Validation of the Lexie Lumen Hearing Aid
Hearing Loss
Primary: Abbreviated Profile of Hearing Aid Benefit (APHAB) — 30.1; 21.4 score on a scale (1-99)