30 closest matches · ranked by relevance
Depression
Primary: Changes in Quantitative Electroencephalogram (qEEG) Prefrontal Cordance (PFC) Over Time (4 Weeks). — -0.54; -0.09; -0.09; -0.88 z-score — p=0.55
Healthy Volunteers
Primary: Change From Baseline in the Changes in Sexual Functioning Questionnaire (CSFQ-14) Total Score Difference for Vortioxetine Versus Paroxetine at Week 5 in Full Analysis…
Depression
Primary: Change in Dopamine Transporter Binding
Healthy
Primary: Area Under the Effect Curve From Time Zero to 24 Hours Postdose of 5-hydroxytryptamine (5-HT) in Plasma — 4183024; 3854399; 4224058; 3912292 pg*hr/mL
Depressive Disorder, Major
Primary: Change From Randomization (Week 0) Associated With GW856553 Versus Placebo at Week 6 in the Bech (6-item HAMD-17 [Hamilton Depression Rating Scale]) Score. — -6.5; -5.6…
Treatment Resistant Major Depressive Disorder
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) Total Score. — 26.881; 28.618; 25.381; 29.718 Units on a scale
Depression
Primary: Changes in Mu-opioid Binding Potential During PET — 0.12 Binding potential ratio — p=<0.001
Depressive Disorder
Primary: Change From Baseline in the Hamilton Depression Scale (HAM-D 17 Items) Total Score — 19.8; 19.4; 14.7; 14.6 Score in scale — p=0.805
Major Depression
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) — 22.519; 23.633 Score on a scale — p=.272
Major Depression
Primary: Model Adjusted Means for Hamilton Depression Rating Score — 20.22; 20.56 score on a scale — p=0.68
Depressive Disorder, Major · Depressive Disorder, Treatment-Resistant
Primary: Incidence of Treatment Emergent Adverse Events (AEs) [Safety and Tolerability] — 9; 15; 12; 0 Participants
MDD · Citalopram · Major Depressive Disorder
Primary: Mean Difference From Baseline to Day 3 in Glutamine/Glutamate (Gln/Glu) Ratio Within Depressed Group — 0.015 arbitrary units
Major Depressive Disorder
Primary: Stockings of Cambridge (SOC) Mean Initial Thinking Time for 3-move Problems — -4485.50 milliseconds
Major Depressive Disorder
Primary: Montgomery-Åsberg Depression Rating Scale (MADRS) — 13.9; 12.7; 14.5; 13.2 units on a scale — p=0.342
Obesity
Primary: Changes in the VAS Score From Baseline. — 2.90; 2.70; -10.8; 6.70 mm
Depressive Disorder, Major
Primary: Mean Change in Hamilton Depression Rating Scale - 17 (HAMD-17) Total Score From Baseline to End of Acute Treatment Phase (Week 8) — -14.5; -15.4 Scores on a scale…
Depressive Disorder
Primary: Adjusted Mean Change From Baseline in the Hamilton Depression Rating Scale (HAM-D; 17 Items) Total Score at Week 8 — -10.4; -12.8; -12.5 scores on a scale — p=<0.001
Major Depressive Disorder
Primary: Number of Dose Limiting Toxicity of Physical Examination — 0; 0 participants
Major Depressive Disorder
Primary: Change From Baseline in Hamilton Depression Rating Scale (HAMD-17) Total Score at Weeks 8 — -9.0; -7.4 Scores on a scale — p=0.121
Major Depressive Disorder · Dysthymic Disorder · Depressive Disorder, NOS
Primary: Hamilton Rating Scale for Depression (HRSD) — 13.3 score on a scale
Anxiety Disorders
Primary: Change From Baseline in Corrected QT Interval by Fridericia (QTcF Interval) — 1.9; 1.0; 0.9; 2.2 Milliseconds
Major Depression
Primary: Hamilton Depression Rating Scale (HAM-D) Effect Seven Days After Dosing (D7) — 16.92; 9.72 score on a scale
Major Depressive Disorder (MDD)
Primary: Change in Total MADRS Scores From Baseline to Week 8 — -24.95; -18.95; -23.89 units on a scale
Major Depressive Disorder
Primary: Incidence of Treatment Emergent Adverse Events — 23; 43 Participants
Depressive Disorder, Major
Primary: Change From Randomization to the End of Treatment Phase (Week 6) in the Bech Melancholia Subscale (Bech) (Items 1, 2, 7, 8, 10 and 13) From the Hamilton Rating Scale for…
Major Depressive Disorder
Primary: Change From Baseline in MADRS Total Score at Week 8 — -19.36; -18.16 units on a scale — p=0.199
Major Depressive Disorder · Healthy Controls
Primary: Money Earned — 23.2; 25.0; 20.5; 21.9 US Dollars
Major Depressive Disorder
Primary: Serum Brain-derived Neurotrophic Factor (BDNF) Levels — 6077.270; 4393.24 pg/mL
Depressive Disorder, Major
Primary: Mean Blood Oxygenation Level Depend (BOLD) Signal % Change in an Emotional Paradigm, Based on the Emotional Faces From the Warsaw Set of Emotional Facial Expression…
Major Depressive Disorder
Primary: Number of Responders 24-hours Post-ketamine Infusion — 3; 1; 3; 2 participants