Clinical Trial Search

Primary: Annualized LRNC Volume Change in Carotid Plaque Composition, as Assessed by MRI — -4.6; -15.1; -9.4 mm^3/year

Primary: Changing LDL Cholesterol — 100; 70 Mg/dl

Primary: C-Reactive Protein (CRP) — 3.7; 4.6 mg/L

Primary: Change in Necrotic Core Volume — 0.07 mm^2

Primary: Table 1 Study Specific Characteristic Part One — 69.8; 59.8; 59.1; 72.7 Percentage of Participants — p=>0.05

Primary: Percent Change in Atheroma Volume (PAV) in the Thoracic Aorta of Spironolactone vs. Placebo — 0.5; 7.3 percentage change — p=0.0293

Primary: Change From Baseline in Common Carotid Artery Intima-Media Thickness (IMT) — 0.877; 0.879; 0.036; 0.033 mm

Primary: Change in Nitric Oxide Formation From Baseline to 3 Months. — 10.0; 11.2; 10.0; 11.0 ng/mL

Primary: Change in Carotid Intima-media Thickness From Baseline to Year 1 — 0.766; 0.765; 0.758; 0.768 millmeter — p=0.7279

Primary: Coronary and Aortic Plaque Inflammation — 0.04; -0.05; -0.03; -0.06 ratio

Primary: Change From Baseline in Carotid Femoral-Pulse Wave Velocity at Month 6 — 1.07; 0.99 meters per second (m/s)

Primary: Arterial Stiffness (Carotid Artery Compliance) During Saline — 1.31; 1.34; 0.90; 1.02 mm2/mm Hg×10-1

Primary: Change From Baseline in Percent Atheroma Volume (PAV) to Month 18 — 40.593; 40.422; 41.013; 40.182 percent (absolute change)

Primary: Change in Mean of Wall Volume of Internal Carotid Arteries — -3.52; -5.91 Other - mm^3 ( cubic millimeter )

Primary: Flow-mediated, Endothelium-dependent Vasodilation — 6.8; 8.7 percentage vasodilation

Primary: Change in Nitric Oxide Formation From Baseline to 3 Months — 27.6; 27.0; 31.4; 25.7 ng/mL

Primary: The Composite of Cerebral Ischemic Stroke and Transient Ischemic Attack — 0; 0; 0; 1 Participants — p=0.462

Primary: Measurement Bias of Calcification Analyzed by vascuCAP™ Non-invasively Relative to Histopathology as Ground Truth. — -0.47; .07 mm2

Primary: Progression Rates of Low Attenuation Plaque Under Influence of Vascepa as Compared to Placebo as a Change Between Two or More Time Points — -0.3; 0.9 volume in mm cubed

Primary: Mean Coronary Wall Thickness — 2.0 mm

Primary: Myocardial Perfusion at Rest — 55; 135 IU/s

Primary: CT Angiography Plaque — 0.17; -1.53 percent change of low attenuation plaque

Primary: Number of Participants With Adverse Events, Serious Adverse Events and Death — 80; 77; 14; 25 Number of participants

Primary: Number of Participants Analyzed for Coronary Calcium Burden by AGS — 9; 11 Participants

Primary: Change From Baseline in Reactive Hyperemia Index at 5 and 10 Months — 1.9; 1.5; 2.01; 1.55 arbitrary units — p=<0.05

Primary: Annualized Rate of Change in Mean of the Maximum (MeanMax) CIMT Measurements From Each of the 12 Carotid Artery Sites Based on All Scans Performed During the 104-Week…

Primary: Percent Change From Baseline in Mean Wall Thickness — 4.245; 6.679 Percent Change

Primary: Coronary Endothelial Function Measured by Percent Change in Coronary Blood Flow With Exercise (%) at 8 Weeks — 8.1; 13.4 Percent change from rest measurement

Primary: Changes in Aortic Valve Calcium Levels — 65; 215 Arbitrary Units — p=0.05

Primary: Change From Baseline in Percent Atheroma Volume(PAV) After 104 Weeks of Treatment — -0.33; 0.11 percentage of baseline