Phase 3
Completed N=58
Inflammation and Vascular Function in Atherosclerosis
Source: ClinicalTrials.gov NCT00760019 ↗Enrolled (actual)
58
Serious AEs
0.0%
Results posted
Apr 2017
Primary outcomePrimary: Flow-mediated, Endothelium-dependent Vasodilation — 6.8; 8.7 percentage vasodilation
◆ Published Evidence
Established
37citations · ~3 / year
The effect of salsalate therapy on endothelial function in a broad range of subjects.
Summary
The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.
Linked Publications (2)
-
The effect of salsalate therapy on endothelial function in a broad range of subjects.
-
The Role of Serum Free Fatty Acids in Endothelium-Dependent Microvascular Function.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Flow-mediated, Endothelium-dependent Vasodilation |
6.8; 8.7 | — |
Eligibility Criteria
Inclusion Criteria
- Non-smoking adult subjects with known atherosclerosis
Exclusion Criteria
- Uncontrolled hypertension (> 140/90 mmHg)
- Untreated hypercholesterolemia (LDL > 160 mg/dL)
- Diabetes mellitus
- Alanine Aminotransferase > 150
- Creatinine > 1.4 mg/dL
- Concommitant use of warfarin
Data sourced from ClinicalTrials.gov (NCT00760019) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.