30 closest matches · ranked by relevance
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Primary: Change in Mean Serum Copeptin From Baseline (a Reflection of Endogenous Vasopressin Production) at Week 2 — -0.86; 0.39 pmole/L — p=<0.01
Kidney, Polycystic, Autosomal Dominant
Primary: Change in Urine cAMP Concentration and Urine Osmolality (UOsm) — -2.6; -2.0 fold change in cAMP/UOsm (umol/UOsm)
Polycystic Kidney, Autosomal Dominant
Primary: Change From Baseline (CFB) in Total Kidney Volume (TKV) at Month 25 — 1686.38; 1418.96; 1487.48; 1670.33 centimeter cube (cm^3) — p=<0.0001
Polycystic Kidney, Autosomal Dominant
Primary: Change in the Gastrointestinal Symptoms Rating Scale (GSRS) to 24 Months — -0.04; -0.11 score on a scale — p=0.50
Chronic Kidney Disease · Autosomal Dominant Polycystic Kidney Disease
Primary: The Mean Annualized Change in eGFR From Pretreatment Baseline to Post-treatment Follow-up. — -2.339; -3.610 mL/min/1.73 m^2/year — p=<0.0001
Polycystic Kidney Disease
Primary: Safety: Total Body Water — 45.78; 44.17 Ohms — p=0.024
ADPKD
Primary: Change From Baseline in Flow Mediated Dilation at 6 Months. — -0.2; -0.4 Percent change.
Autosomal Dominant Polycystic Kidney Disease
Primary: Primary Efficacy Analysis of Total Kidney Volume (mITT Set, Multiple Imputation) — 230.1; 300.8 mL
Kidney, Polycystic
Primary: Study A: Percent Annual Change in Total Kidney Volume — 6.0; 6.2; 5.6; 6.6 percentage of Total Kidney Volume — p=0.52
Polycystic Kidney Disease, Autosomal Dominant
Primary: Percentage Change Per Year in Total Kidney Volume From Baseline to Month 36 — 2.777; 5.608 Percentage change per year — p=<0.0001
Autosomal Dominant Polycystic Kidney Disease
Primary: Total Kidney Volume — 1428; 1675; 1728; 1775 mL
Autosomal Dominant Polycystic Kidney · Hypertension · Endothelial Dysfunction
Primary: Change in Clinic Systolic and Diastolic Blood Pressure From Baseline to 4 Weeks (End of Study) — -5.36; -7.65; -3.55; -2.73 mmHg
Polycystic Kidney, Autosomal Dominant
Primary: Percent of Participants Demonstrating 20% or More Increase in Total Kidney Volume — 69; 88 percentage of participants — p=0.03
Autosomal Dominant Polycystic Kidney Disease
Primary: Maximum Observed Plasma Concentration (Cmax) of Lixivaptan in ADPKD Patients — 656.8; 190.9; 681.3; 156.9 ng/mL
Polycystic Kidney, Autosomal Dominant
Primary: Feasibility to Enroll and Retain Participants — 122 Participants
Autosomal Dominant Polycystic Kidney Disease
Primary: Mean Change From Baseline in Measured Glomerular Filtration Rate (mGFR) After 3 Weeks of Tolvaptan Treatment and at 3 Weeks Post Treatment. — -8.0; -6.2; -0.7; 0.1…
Polycystic Kidney, Autosomal Dominant
Primary: Phase 1b: Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious Adverse Events (SAE) — 24; 8; 5; 1 Participants
Autosomal Dominant Polycystic Kidney Disease
Primary: Total Kidney Volume — 1500.5; 1573.1; 1567.9; 1729.4 mL
Polycystic Kidney, Autosomal Dominant
Primary: Safety Assessments Based on Vital Signs, Electrocardiogram (ECG's), Clinical Laboratory Tests, Physical Examinations Are Reported as Adverse Events (AEs) Upon Study…
Kidney, Polycystic
Primary: Number of Participants With 50% Reduction of Baseline eGFR, End Stage Renal Disease (ESRD, Initiation of Dialysis or Preemptive Transplant), or Death. — 116; 115…
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Primary: Phase A: Change From Baseline in Spot Urine Osmolality (Pre-morning Dose) — 635; 646; -386; -93 milliosmoles per kilogram (mOsm/kg)
Polycystic Kidney Diseases
Primary: Change in GFR From Baseline to 12 Months — 72.8; 70.3; 73.1; 74.4 ml/min/1.73m^2 — p=<0.01
Polycystic Kidney, Autosomal Dominant
Primary: Number Of Participants Reporting Treatment-Emergent Adverse Events (TEAEs) — 473; 531; 640; 6 participants
Polycystic Kidney, Autosomal Dominant
Primary: Percent Change in Brachial Artery Flow-mediated Dilation (FMD-BA) — 1.14; 0.3 percent change
Polycystic Kidney, Autosomal Dominant
Primary: Safety and Tolerability of Metformin — 50; 100; 82; 100 percentage of participants
Autosomal Dominant Polycystic Kidney Disease （ADPKD)
Primary: Total Kidney Volume — 1812.38; 1878.82; 1934.14; 2214.28 mL
Autosomal Dominant Polycystic Kidney Disease
Primary: Percent Change From Baseline in Total Kidney Volume (TKV) at Week 3 — -2.46; -2.55; -1.17; 0.09 Percentage change — p=0.0127
Polycystic Kidney, Autosomal Dominant
Primary: Estimated Slope of Total Kidney Volume During Pre-administration and Administration — 6.7517; 3.6811 %/year
Autosomal Dominant Polycystic Kidney · ADPKD
Primary: Change From Baseline in Height Adjusted Total Kidney Volume (htTKV) at Month 12 — 0.0236; 0.0288 milliliters per meter — p=0.5265
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Primary: Percent Change From the Baseline in Total Kidney Volume (TKV) for Study 156-04-251 Participants Enrolled in This Study (156-08-271) — 28.66; 30.58 percent change — p=0.358