N/A N=19 Bipolar Disorder in Late Life
Bipolar Disorder
Primary: Boyko DWM Hyperintensity Value >2 in Subjects Who Received Acute Treatment for Mania — 10; 9 participants — p=>0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=13 Examining the Effect of EEG-guided Theta Burst Stimulation in Bipolar Disorder
Bipolar Disorder
Primary: Brain Activity (Beta Power) in Left vLPFC — -88.78; 1437.64; 13.43; -128.00 Percentage of change post versus pre — p=0.29389090
N/A N=44 Transcranial Direct Current Stimulation Therapy for Bipolar Depression
Depression, Bipolar · Bipolar Disorder · Mood Disorders
Primary: Number of Participants With Clinical Response [ Time Frame: At 6 Weeks Following Course of tDCS Treatment ] — 34 Participants
Phase 4 N=189 Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
Bipolar Disorder · Major Depression
Primary: HAM-D 17 Item: Hamilton Depression Rating Scale — 6.6; 4.91; 2.333; 3.75 score on a scale
N/A N=76 PET and MRI Brain Imaging of Bipolar Disorder
Bipolar Disorder · Bipolar Depression · Unipolar Depression
Primary: Post-Lithium Treatment Hamilton Depression Rating Scale (HDRS) — -44.49 Percent Change in HDRS-24 Score
Phase 4 N=46 FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
Bipolar Disorder
Primary: 17-item Hamilton Depression Rating Scale (HDRS) — 20; 6; 6; 2 units on a scale
N/A N=26 Decision-Making in Bipolar Disorder
Bipolar Disorder
Primary: Change in Vigilance Assessed by the Melbourne Decision Making Questionnaire (MDMQ) — .176 units on a scale
N/A N=60 Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Bipolar Disorder · Alcohol Drinking · Alcohol Use Disorder
Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…
Phase 4 N=21 Brexpiprazole for Bipolar Depression
Bipolar Depression
Primary: The Montgomery-Asberg Depression Rating Scale (MADRS) — 31.95; 9.95; 10.95 score on a scale — p=<.001
Phase 4 N=86 Maintenance Treatment of Bipolar Depression
Bipolar Disorder · Depression
Primary: Mania Rating Scale — 4.54; 5.57 units on a scale
Phase 2 N=341 A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression
Depressive Episode · Bipolar 1 Depression
Primary: Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score at Week 6 — -19.485; -19.324; -16.196 units on a scale — p=0.044
Phase 4 N=40 Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
Bipolar Disorder
Primary: Montgomery-Asberg Depression Rating Scale — -39.24 Percent change in MADRS from baseline
Phase 3 N=54 Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Bipolar Disorder
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -9.64; -5.32 units on a scale
Phase 3 N=258 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group-comparison Trial of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode
Bipolar I Disorder
Primary: Young Mania Rating Scale (YMRS) — -11.3; -5.3 scores on a scale — p=<0.001
Phase 4 N=112 Sequential Multiple Assignment Treatment for Bipolar Disorder
Bipolar I Disorder · Bipolar II Disorder
Primary: Bipolar Inventory of Symptoms Scale (BISS) — -0.31; -0.41; 0.15; -0.38 calculated mean scale score
Phase 3 N=514 Olanzapine Treatment of Patients With Bipolar I Disorder
Depression, Bipolar
Primary: Change From Baseline to Endpoint in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score (Acute Phase) — 29.36; 28.69; -14.26; -11.71 units on a scale — p=0.018
N/A N=20 Bipolar Intervention Study: Cognitive Interpersonal Therapy
Mania · Hypomania · Bipolar Affective Disorder
Primary: Montgomery Asberg Depression Rating Scale (MADRS) (Montogomery and Asberg, 1979) — 26.20; 20.20; 16.11; 15.22 units on a scale — p=0.05
N/A N=7 Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
Bipolar Disorder · Depression
Primary: K SADS-Present Version (KSADS-P) — 0; 2; 1; 0 participants
N/A N=29 Pilot Study of Cognitive Behavioral Therapy for Anxiety and Bipolar I Disorder
Bipolar Disorder · Anxiety Disorders
Primary: Reductions Over Time in Anxiety Symptoms as Measured by Hamilton Anxiety Rating Scale — 14; 18.81; 11.78; 17.70 Units on scale — p=.02
Phase 4 N=41 Iloperidone in Mixed States of Bipolar Disorder
Bipolar Disorder
Primary: Measure of Response by Change From Baseline to End of Study in BISS Depression and Mania Scale Scores — 35.7; 61.8; 25; 48 percentage change in score on BISS scale…
Phase 4 N=92 Acute Psychotherapy for Bipolar II Depression
Bipolar Disorder · Depression
Primary: Remission — 16; 13 Participants — p=<0.0001
Phase 4 N=202 A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients
Bipolar I Disorder
Primary: Mean Change in Young Mania Rating Scale (YMRS) Scores From Baseline to Endpoint. — -10.15; -7.68 units on a scale — p=<0.001
Phase 4 N=43 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder
Alcohol Dependence · Bipolar Disorder · Depression
Primary: Percent Days Abstinent From Alcohol — 78.7; 80.1 Percentage of days abstinent
Phase 3 N=31 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
Bipolar Disorder
Primary: Time to Treatment for Emerging Symptoms of a Mood Relapse — 17.8; 15.9 weeks
N/A N=27 Reasoning Training in Individuals With Bipolar Disorder
Bipolar Disorder · Cognitive Ability, General
Primary: Change From Baseline: Test of Strategic Learning — 2.35; 3.04 score on a scale — p=0.040
Phase 3 N=224 Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder
Bipolar Disorder
Primary: Change From Baseline to 3 Week Endpoint in Young Mania Rating Scale (YMRS) Total Score — -12.6; -14.3; -6.8 units on a scale — p=<0.001
N/A N=14 Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation
Bipolar Disorder · Schizo Affective Disorder
Primary: Young Mania Rating Scale (YMRS) — 5.5; 11.8; 7.5; 3 score on a scale
Phase 4 N=107 Cost- Effectiveness and Quality of Life Assessment in Mood Disorder
Bipolar Disorder
Primary: Number of Participants With Response to Treatment" — 31; 28; 27 Participants
Phase 4 N=129 Antidepressant Therapy in Treating Bipolar Type II Major Depression
Bipolar Disorder · Depression
Primary: Depressive Relapse — 3; 4 Participants
Phase 4 N=177 Prevention of Relapse & Recurrence of Bipolar Depression
Bipolar Disorder
Primary: Number of Participants With Relapse of Major Depressive Episode Within 1 Year — 4; 5 Participants