N/A N=27 Supportive Care

Reasoning Training in Individuals With Bipolar Disorder

Bipolar Disorder · Cognitive Ability, General

Bottom Line

View on ClinicalTrials.gov: NCT02843282 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Dec 2024

Primary outcome: Primary: Change From Baseline: Test of Strategic Learning — 2.35; 3.04 score on a scale — p=0.040

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Advanced Reasoning Training (Behavioral)
Age: Adult, Older Adult · 20+ yrs
Sex: All
Sponsor: The University of Texas at Dallas
Primary completion: Sep 2015

Outcome Measures

Outcome	Result	p-value
PRIMARY Change From Baseline: Test of Strategic Learning	2.35; 3.04	0.040 sig
SECONDARY Change From Baseline: Wechsler Adult Intelligence Scale (WAIS), Similarities Subtest	12.63; 13.62	0.004 sig
SECONDARY Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Card Sorting	11.70; 13.56	<0.001 sig
SECONDARY Change From Baseline: Working Memory (Digits Backwards)	6.78; 7.30	0.039 sig
SECONDARY Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Color-Word, Inhibition & Switching Subtest	11.04; 11.46	0.092
SECONDARY Change From Baseline: Divided Attention	73.44; 66.86	0.052
SECONDARY Change From Baseline: Verbal Fluency	11.30; 11.82	0.121
SECONDARY Change From Baseline: Rey Auditory Verbal Learning Test (RAVLT)	9.70; 10.93	0.019 sig
SECONDARY Change From Baseline: Logical Memory	11.89; 12.26	0.278
SECONDARY Change From Baseline: Quality of Life in Bipolar Disorder (QoL.BD)	176.93; 183.93	0.095
SECONDARY Resting State Relative Cerebral Brain Blood Flow (rCBF)	0.67; 0.82	< 0.01 sig
SECONDARY Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Accurate Description of Sorts	11.74; 12.96	0.001 sig
SECONDARY Change From Baseline: Delis-Kaplan Executive Function System (DKEFS) Accurate Recognition of Sorts	11.56; 12.89	0.007 sig

Summary

The purpose of this study is to examine cognitive and brain changes in individuals with bipolar disorder as a result of a cognitive training intervention.

Eligibility Criteria

Inclusion Criteria

Must have physician or psychiatrist authorization form confirming participant fulfills 4 criteria:
has diagnosis of Bipolar I or II
has been stable and consistent with medication for last 3 months
is in a euthymic, rather than manic or depressive, state
is appropriate for a group-based intervention

EXCLUSION CRITERIA

Not a native English speaker
Less than 12 years education
Additional psychiatric diagnosis

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT02843282). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.