Phase 3 N=193 Study of Postoperative Analgesia in Bunionectomy
Bunion · Hallux Valgus
Primary: Area Under the Curve (AUC) of the Numeric Rating Scale at Rest (NRS-R) Pain Intensity Scores — 124; 146 Units on a scale*hours
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=100 Bunionectomy Study (0000-063)
Acute Pain
Primary: Total Patient Controlled Analgesic (PCA) Hydromorphone Consumption Over the 24 Hours Post-surgery — 2.94; 2.07; 5.96 milligrams — p=0.005
Phase 3 N=412 Bunionectomy Study for Postoperative Analgesia (EPOCH 1)
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) Pain Intensity Scores With Activity (NRS-A) Through 72 Hours Postsurgery (AUC0-72), Compared With…
Phase 2 N=192 A Study of MDT-10013 in the Treatment of Acute Postoperative Pain Following Bunionectomy
Postoperative Pain
Primary: Summed Pain Intensity Over 1- 48hrs (SPI-48) From Cohort 1 to 3 — 252.29; 213.28; 191.97; 215.35 units on a scale
Phase 2 N=59 Placebo-Controlled Evaluation of N1539 Following Bunionectomy Surgery
Pain, Post-operative
Primary: Number of Subjects With Adverse Events — 12; 10; 10 Participants
Phase 2 N=78 Phase 2 Bunionectomy HTX-011 Administration Study
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the NRS-A (Windowed Worst Observation Carried Forward) Pain Intensity Scores — 278.36; 288.23; 126.93 pain intensity score*hr
Phase 3 N=201 Evaluation of N1539 Following Bunionectomy Surgery
Pain, Post-operative
Primary: Summed Pain Intensity Difference Over the First 48 Hours (SPID48) — -6956.0; -4829.3 units on a scale — p=0.0034
Phase 2 N=87 A Phase 2 Study to Evaluate Pregabalin and Acetaminophen Compared to Acetaminophen and Placebo in Subjects Undergoing Bunionectomy
Postoperative Pain
Primary: Summed Pain Intensity (SPI) Between Group A and Group C — 153.08; 267.51 score on a scale — p=<0.001
Phase 3 N=428 Study of Diclofenac Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48), ANCOVA Model…
Phase 3 N=373 Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48) — 598.670; 623.162…
Phase 3 N=462 Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
Other Acute Postoperative Pain
Primary: The Time-Weighted Summed Pain Intensity Difference Measured Using the 100-mm Visual Analogue Scale From 0 to 48 Hours After Trial Entry (VASSPID-48) — 508.2; 329.8…
Phase 2 N=100 Acute Pain Study Following Bunionectomy
Pain
Primary: Sum of Pain Intensity Difference (SPID) Using the Pain Intensity Visual Analog Scale (VAS) — 259.0; 39.4 scores on a scale
Phase 3 N=200 Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Pain, Postoperative
Primary: Average Numeric Pain Rating Score (NPRS) Over 48 Hours After Bunionectomy — 3.3; 5.7 units on a scale
Phase 2 N=430 Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy
Postoperative Pain · Bunions
Primary: Mean Summed Pain Intensity (SPI) Score Over 24 Hours — 69.16; 96.83; 83.38; 85.70 Units on a scale
Phase 3 N=201 Multicenter Study to Evaluate the Analgesic Efficacy of XP21L in Subjects With Pain Following Bunionectomy Surgery
Pain, Postoperative
Primary: Average Numeric Pain Rating Score (NPRS) Over 48 Hours After Bunionectomy — 2.5; 5.6 units on a scale
Phase 2 N=250 Hydrocodone/Acetaminophen for Acute Pain Following Bunionectomy
Pain
Primary: Sum of Pain Intensity Difference (SPID) Using the Pain Intensity Visual Analogue Scale (VAS) — 720.5; 239.9; 614.4; 450.8 scores on a scale
Phase 2 N=274 A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Acute Pain
Primary: Time-Weighted Sum of Pain Intensity Difference (SPID) as Recorded on a Numeric Pain Rating Scale (NPRS) 0 to 48 Hours (SPID48) After the First Dose of Study Drug…
Phase 2 N=147 Study of CA-008 (Vocacapsaicin) in Bunionectomy Patients
Post-surgical Pain
Primary: Change in Postsurgical Pain Based on the Weighted Sum of Pain Intensity (SPI) Assessments Over 96 Hours of the NRS Scores = Area Under the Curve (AUC) — 317.09; 321.72…
Phase 3 N=405 Safety/Efficacy Study of Oxycodone HCl/Niacin to Treat Pain After Bunionectomy
Pain
Primary: SPID48 — 604.48; 998.46; 1224.97 score on a scale
Phase 3 N=1,075 Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Acute Pain
Primary: Time-weighted Sum of the Pain Intensity Difference (SPID) as Recorded on a Numeric Pain Rating Scale (NPRS) From 0 to 48 Hours (SPID48), SUZ Compared to Placebo — 70.6…
Phase 3 N=276 Maxigesic IV Phase 3 Bunionectomy Study
Post Operative Pain
Primary: Summed Pain Intensity Difference (SPID)-Calculated From the Pain Intensity Scores Recorded on a 100mm Long Scale With Anchors for "no Pain" (0 mm) and "Worst Pain…
Phase 2 N=36 Open-Label CA-008 (Vocacapsaicin) in Bunionectomy
Pain
Primary: Area Under the Curve (AUC) of Numerical Rating Scale (NRS) Scores (at Rest) Over 72h — 72.30; 66.24; 203.76; 306.58 score on a scale*hour
Phase 3 N=409 Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy
Pain Management
Primary: The Sum of Pain Intensity Differences (SPID) Through 48 Hours Post First Dose — -122.8; -110.9; -97.8 score on a scale — p=<.005
Phase 2 N=58 Safety, Efficacy, and Pharmacokinetics of SKY0402 Administered as a Nerve Block in Subjects Undergoing Bunionectomy
Postoperative Pain
Primary: Time to First Use of Supplemental Pain Medication Postoperatively for Surgical Pain — 9.4; 1.9; 1.2; 2.4 hours
Phase 2 N=239 Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy
Acute Postoperative Pain · Bunionectomy
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) of Pain Intensity Scores From Time 0 (When First Dose on Day 1 is Administered) Through 24 Hours…
Phase 2 N=243 A Study to Evaluate Efficacy and Safety of VX-150 in Subjects With Acute Pain Following Bunionectomy
Acute Pain
Primary: Time-weighted Sum of the Pain Intensity Difference (SPID) Between VX-150 Versus Placebo as Recorded on a Numeric Pain Rating Scale (NPRS) 0 to 24 Hours After the First…
Phase 3 N=450 XG005 for Pain Control in Subjects Undergoing Bunionectomy
Acute Pain
Primary: Compared the Summed Pain Intensity From the End of Surgery to 48 Hours (SPI48) Between the High-dose XG005 Group and the Placebo Group Postoperatively. — 132.63; 285.99…
Phase 3 N=329 Safety and Efficacy of COV795 in Moderate to Severe Post-Operative Bunionectomy Pain With an Open-label Extension
Pain, Postoperative · Bunion
Primary: SPID48 (Summed Pain Intensity Difference) — 114.9; 66.9 scores on a scale
Phase 3 N=66 Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy
Bunionectomy · Hallux Valgus
Primary: NRS Pain Scores Through 96 Hours Post-surgery — 342.3; 201.3; 377.4 units on a scale*hours — p=<0.00001
Phase 3 N=291 A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy
Bunionectomy · Pain · Postoperative Pain
Primary: Sum of Pain Intensity Differences Relative to the Baseline Pain Intensity. — 46.2; 102.5; -17.5 units — p=<0.0001