N/A N=21 Influence of Yogic Breathwork on CSF Circulation
CSF Circulation
Primary: CSF Flow Velocities — 1.36; 1.31; 1.48; 1.15 cm/s
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=37 Ventriculostomies in SAH: ICP Open or Not?
Subarachnoid Hemorrhage
Primary: Cerebral Artery Vasospasm — 16; 7 Participants
N/A N=8 Cerebrospinal Fluid (CSF) Pharmacokinetics of Antimicrobials in Children
Infections
Primary: CSF:Serum Ratio of Vancomycin — 0.08 ratio
N/A N=44 Assessment of CSF Shunt Flow With Thermal Measurements A
Hydrocephalus
Primary: Study Device Sensitivity — 88 percent
N/A N=5 Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension
Intracranial Hypotension
Primary: Intracranial Pressure Measurements Estimated by the MRICP Technique. — 6.5 cm H20
N/A N=141 Assessment of CSF Shunt Flow With Thermal Measurements B
Hydrocephalus
Primary: Study Device Sensitivity — 88.9 percent of ground truth positive cases
N/A N=5 Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters
Hydrocephaly
Primary: To Demonstrate That the Flusher Can be Primed, Connected, and Activated in a Sterile Clinical Setting Per the Instructions for Use by the Treating Investigator . — 4; 4…
N/A N=19 CSF Pharmacokinetics of Ondansetron
Pain
Primary: CSF to Plasma Concentration Ratio — 0.15 Ratio
Phase 2 N=10 Pharmacokinetics of Ceftolozane/Tazobactam in Plasma and Cerebrospinal Fluid
Pharmacokinetics
Primary: Unbound Ceftolozane Exposure in the Plasma — 322.6 mg*h/L
Phase 2 N=28 Circadian Rhythms of Aqueous Humor Dynamics in Humans
Glaucoma
Primary: Intraocular Pressure — 17.6; 16.4; 20.2; 17.0 mmHg — p=<.05
N/A N=15 Circadian Macular Volume Changes in the Choroid
Choroid Physiology
Primary: Macular Choroidal Volume — 10.33 mm^3
N/A N=14 Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
Breast Cancer · Leptomeningeal Metastasis
Primary: Total Number of Participants With Leptomeningeal Metastasis Detected (ER Status) — 3; 1 Participants
Phase 1 N=14 The Rilpivirine Cerebrospinal-fluid (CSF) Study
HIV
Primary: CSF:Plasma Ratio of Rilpivirine Levels — 1.4 ratio expressed as a percentage
N/A N=4 Convection Enhanced Delivery of CSF in DBS for Parkinson's
Parkinson Disease
Primary: Number of Participants With Adverse Events That Are Related to Treatment — 2 Participants
N/A N=33 FILtration of Subarachnoid Hemorrhage Via SpinaL CAtheteR Extension
Subarachnoid Hemorrhage
Primary: Mean Change in Cisternal Blood From Enrollment to Catheter Removal — -64.7 percent change
N/A N=10 Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome
Hunter Syndrome
Primary: Levels of Total Glycosaminoglycan (GAG) in CSF — 816.750 ng/mL
N/A N=12 Internal Jugular Vein Flow in the Sitting Position
Jugular Venous Flow
Primary: Internal Jugular Venous Flow — 0.04; 0.4; 0.04; 0.21 cm2
N/A N=10 Blood Volume and Fluid Kinetics in Patients Undergoing Extracorporal Circulation
Blood Volume, Extravasation
Primary: Blood Volume — 4.61 Litre
N/A N=48 Sleep Quality and Amyloid-Beta Kinetics
Amyloid-beta
Primary: Difference in Amyloid-beta (Abeta) Concentration in the CSF (Cerebral Spinal Fluid) of Individuals With Poor Sleep Efficiency Compared to Those With Good Sleep…
N/A N=60 Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Brain Neoplasms · Surgery · Hyperemia
Primary: Mean Blood Flow Velocity in Middle Cerebral Artery — 63.7; 61.8 cm/s — p=0.554
N/A N=231 Lumbar Puncture and Syphilis Outcome
Syphilis
Primary: Appropriate Decline in Serum Rapid Plasma Reagin Test (RPR) Titer — 38; 30 Participants — p=0.29
N/A N=1 Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging
Traumatic Brain Injury · Multiple Sclerosis · Alzheimer's Disease
Primary: Regional Cerebral Blood Flow Values of the Brain Measured Using Pseudo-continuous Arterial Spin Labeling (pCASL) MRI. — 35.4 ml/100g/min
N/A N=10 Microembolic Signals and Cerebrospinal Fluid Markers of Neuronal Damage After Surgical Aortic Valve Replacement
Aortic Stenosis
Primary: Transcranial Doppler(TCD) Microembolic Signals During Surgical Aortic Valve Replacement Surgery — 354 units on a scale
N/A N=15 Cerebral Blood Flow During Hemodialysis
Haemodialysis-induced Symptom
Primary: Change in CBF From Baseline (Before Start of the Hemodialysis Study Session), at 20 Minutes, and at the End of the Hemodialysis Study Session, Measured by [15O]H2OPET-CT…
Phase 1 N=20 Assessment of Exposure of BI 409306 in Cerebrospinal Fluid (CSF) Relative to Plasma as Well as to Evaluation of the Effect of Different Doses of BI 409306 on the cGMP (Cyclic Guanosine Monophosphate) Levels in CSF in Healthy Male Volunteers
Healthy
Primary: Ratio of Cmax of BI 409306 in CSF Compared to Plasma — 0.267; 0.244; 0.294; 0.335 Ratio — p=1.0000
Phase 2 N=81 Bolus of Saline in Stroke
Ischemic Stroke
Primary: The Percentage of Change in Optical Cerebral Blood Flow (oCBF) During Bolus Normal Saline Compared to Baseline, as Measured by Diffuse Correlation Spectroscopy (DCS)…
N/A N=30 Chronic Insomnia and CSF Markers of Dementia
Insomnia Chronic
Primary: CSF Markers Related to Dementia — 4332.1; 4824.0; 393.2; 419.4 picograms per milliliter
Phase 1 N=10 Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI
Spinal Cord Injury
Primary: Efficacy-Sensivity Improvement Using the ASIA Score — 188.2; 202.2; 218.4; 228.9 units on a scale